Pituitary Adenylate Cyclase-Activating Polypeptide
A multi-function neuropeptide that acts throughout the body by elevating intracellular cyclic AMP level via its interaction with PACAP RECEPTORS and VASOACTIVE INTESTINAL PEPTIDE RECEPTOR. Although first isolated from hypothalamic extracts and named for its action on the pituitary, it is widely distributed in the central and peripheral nervous systems. PACAP is important in the control of endocrine and homeostatic processes, such as secretion of pituitary and gut hormones and food intake.
Year introduced: 2006(1990)
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Subheadings:
Tree Number(s): D12.644.276.860.887, D12.644.400.625, D12.776.467.860.887, D12.776.631.600.887, D12.776.631.650.625, D23.529.850.887
MeSH Unique ID: D051219
Entry Terms:
- PACAP
- Pituitary Adenylate Cyclase Activating Polypeptide
- Pituitary Adenylate Cyclase Activating Polypeptide 27
- PACAP-27
- PACAP27
- Pituitary Adenylate Cyclase Activating Polypeptide 38
- PACAP-38
- PACAP38
Pharmacologic Action: