12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)

Year introduced: 1997

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Tree Number(s): D10.251.355.255.100.300.425, D10.251.355.310.166.550.425

MeSH Unique ID: D019377

Registry Number: 59985-28-3

Entry Terms:

• 12-HETE
• 12-R-HETE
• 12-S-HETE
• 12-S-Hydroxyeicosatetraenoic Acid
• 12 S Hydroxyeicosatetraenoic Acid
• Acid, 12-S-Hydroxyeicosatetraenoic

Previous Indexing:

• Arachidonic Acids (1975-1984)
• Fatty Alcohols (1975-1976)
• Hydroxy Acids (1976-1978)
• Hydroxyeicosatetraenoic Acids (1985-1996)

All MeSH Categories
Chemicals and Drugs Category
Lipids
Fatty Acids
Fatty Acids, Unsaturated
Eicosanoids
Arachidonic Acids
Hydroxyeicosatetraenoic Acids
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

All MeSH Categories
Chemicals and Drugs Category
Lipids
Fatty Acids
Fatty Acids, Unsaturated
Fatty Acids, Essential
Arachidonic Acids
Hydroxyeicosatetraenoic Acids
12-Hydroxy-5,8,10,14-eicosatetraenoic Acid