Farnesyl-Diphosphate Farnesyltransferase
The first committed enzyme of the biosynthesis pathway that leads to the production of STEROLS. it catalyzes the synthesis of SQUALENE from farnesyl pyrophosphate via the intermediate PRESQUALENE PYROPHOSPHATE. This enzyme is also a critical branch point enzyme in the biosynthesis of ISOPRENOIDS that is thought to regulate the flux of isoprene intermediates through the sterol pathway.
Year introduced: 2006(1975)
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Subheadings:
Tree Number(s): D08.811.913.225.431
MeSH Unique ID: D013186
Registry Number: EC 2.5.1.21
Entry Terms:
- Farnesyl Diphosphate Farnesyltransferase
- Farnesyltransferase, Farnesyl-Diphosphate
- Farnesyldiphosphate-Farnesyldiphosphate Farnesyltransferase
- Farnesyldiphosphate Farnesyldiphosphate Farnesyltransferase
- Farnesyltransferase, Farnesyldiphosphate-Farnesyldiphosphate
- FPP-FPP Farnesyl Transferase
- Farnesyl Transferase, FPP-FPP
- FPP FPP Farnesyl Transferase
- Transferase, FPP-FPP Farnesyl
- Presqualene-Diphosphate Synthase
- Presqualene Diphosphate Synthase
- Synthase, Presqualene-Diphosphate
- Squalene Synthase
- Synthase, Squalene
- Squalene Synthetase
- Synthetase, Squalene
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