11-beta-Hydroxysteroid Dehydrogenase Type 2
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
Year introduced: 2004
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Subheadings:
Tree Number(s): D08.811.682.047.436.174.600, D08.811.682.047.820.100.600
MeSH Unique ID: D043209
Registry Number: EC 1.1.1.146
Entry Terms:
- 11 beta Hydroxysteroid Dehydrogenase Type 2
- 11 beta-HSD2
- 11 beta-Hydroxysteroid Dehydrogenase Type 2
- 11beta-HSD2
- 11beta-HSD2 Reductase
- 11beta-Hydroxysteroid Dehydrogenase Type 2
- 11beta Hydroxysteroid Dehydrogenase Type 2
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