Pyruvate Dehydrogenase Complex

A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

Year introduced: 1974(1973)

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Tree Number(s): D05.500.562.625, D08.811.600.741

MeSH Unique ID: D011768

Entry Terms:

• Complex, Pyruvate Dehydrogenase
• Dehydrogenase Complex, Pyruvate

Previous Indexing:

• Oxidoreductases (1966-1972)
• Pyruvate Oxidase (1966-1972)
• Pyruvates (1966-1972)

All MeSH Categories
Chemicals and Drugs Category
Macromolecular Substances
Multiprotein Complexes
Multienzyme Complexes
Pyruvate Dehydrogenase Complex
Dihydrolipoamide Dehydrogenase
Dihydrolipoyllysine-Residue Acetyltransferase
Pyruvate Dehydrogenase (Lipoamide)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Multienzyme Complexes
Pyruvate Dehydrogenase Complex
Dihydrolipoamide Dehydrogenase
Dihydrolipoyllysine-Residue Acetyltransferase
Pyruvate Dehydrogenase (Lipoamide)