Von Hippel-Lindau Tumor Suppressor Protein

A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.

Year introduced: 2006 (1995)

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Tree Number(s): D08.811.464.938.750.875, D12.776.624.776.865

MeSH Unique ID: D051794

Registry Number: EC 2.3.2.27

Entry Terms:

• Von Hippel Lindau Tumor Suppressor Protein
• VHL Tumor Suppressor Protein

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Ligases
Ubiquitin-Protein Ligase Complexes
Ubiquitin-Protein Ligases
Von Hippel-Lindau Tumor Suppressor Protein

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Neoplasm Proteins
Tumor Suppressor Proteins
Von Hippel-Lindau Tumor Suppressor Protein