Formate-Tetrahydrofolate Ligase

A carbon-nitrogen ligase that catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate in the presence of ATP. In higher eukaryotes the enzyme also contains METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+) and METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE activity.

Year introduced: 1998(1975)

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Tree Number(s): D08.811.464.259.550

MeSH Unique ID: D005574

Registry Number: EC 6.3.4.3

Entry Terms:

• Formate Tetrahydrofolate Ligase
• Ligase, Formate-Tetrahydrofolate
• Formyltetrahydrofolate Synthetase
• Synthetase, Formyltetrahydrofolate
• Tetrahydrofolate Formylase
• Formylase, Tetrahydrofolate

Previous Indexing:

• Formic Acids (1969-1974)
• Ligases (1969-1974)
• Tetrahydrofolates (1972-1974)

See Also:

• Methylenetetrahydrofolate Dehydrogenase (NADP)
• Methenyltetrahydrofolate Cyclohydrolase

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Ligases
Carbon-Nitrogen Ligases
Formate-Tetrahydrofolate Ligase