Glucose-6-Phosphate Isomerase
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Year introduced: 1998(1965)
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Subheadings:
Tree Number(s): D08.811.399.475.200.350
MeSH Unique ID: D005956
Registry Number: EC 5.3.1.9
Entry Terms:
- Glucose 6 Phosphate Isomerase
- Isomerase, Glucose-6-Phosphate
- Glucosephosphate Isomerase
- Isomerase, Glucosephosphate
- Isomerase, Glucose 6 Phosphate
- Phosphoglucose Isomerase
- Isomerase, Phosphoglucose
- Phosphohexose Isomerase
- Isomerase, Phosphohexose
- Autocrine Motility Factor
- Factor, Autocrine Motility
- Motility Factor, Autocrine
- Neuroleukin
- Tumor Autocrine Motility Factor
- Tumor-Cell Autocrine Motility Factor
- Tumor Cell Autocrine Motility Factor