DNA Topoisomerases

Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA.

Year introduced: 2002

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Tree Number(s): D08.811.399.403

MeSH Unique ID: D026942

Registry Number: EC 5.99.1.-

Entry Terms:

• Topoisomerases, DNA

Previous Indexing:

• DNA Topoisomerase (1977-2001)
• DNA Topoisomerase (ATP-Hydrolysing) (1979-2001)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Isomerases
DNA Topoisomerases
DNA Topoisomerases, Type I
DNA Topoisomerases, Type II
DNA Gyrase
DNA Topoisomerase IV