Pregnancy-Associated Plasma Protein-A

A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.

Year introduced: 2004 (1996)

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Tree Number(s): D08.811.277.656.300.480.632, D08.811.277.656.675.374.632, D12.776.780.700

MeSH Unique ID: D011266

Registry Number: EC 3.4.24.-

Entry Terms:

• Pregnancy Associated Plasma Protein A
• IGFBP-4 Protease
• IGFBP 4 Protease
• Protease, IGFBP-4
• IGFBP-4-Specific Proteinase
• Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
• Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease
• Insulin-Like-Growth Factor Binding Protein-4 Protease
• Insulin Like Growth Factor Binding Protein 4 Protease
• IGFBP-4 Metalloproteinase
• IGFBP 4 Metalloproteinase
• Metalloproteinase, IGFBP-4
• PAPP-alpha
• PAPP alpha
• Pregnancy Associated alpha Plasma Protein
• Pregnancy-Associated alpha-Plasma Protein
• PAPP-A

Previous Indexing:

• Alpha Globulins (1966-1979)
• Alpha Macroglobulins (1976-1979)
• Blood Proteins (1966-1979)
• Glycoproteins (1966-1979)
• Pregnancy (1966-1979)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Peptide Hydrolases
Endopeptidases
Metalloendopeptidases
Pregnancy-Associated Plasma Protein-A

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Peptide Hydrolases
Metalloproteases
Metalloendopeptidases
Pregnancy-Associated Plasma Protein-A

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Pregnancy Proteins
Pregnancy-Associated Plasma Protein-A