Procollagen N-Endopeptidase

An extracellular endopeptidase which excises a block of peptides at the amino terminal, nonhelical region of the procollagen molecule with the formation of collagen. Absence or deficiency of the enzyme causes accumulation of procollagen which results in the inherited connective tissue disorder--dermatosparaxis. EC 3.4.24.14.

Year introduced: 1997

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Tree Number(s): D08.811.277.656.300.480.664, D08.811.277.656.675.374.664

MeSH Unique ID: D011348

Registry Number: EC 3.4.24.14

Entry Terms:

• Procollagen N Endopeptidase
• Procollagen N-Proteinase
• Procollagen N Proteinase
• Procollagen Peptidase

Previous Indexing:

• Collagen (1966-1976)
• Peptide Peptidohydrolases (1966-1976)
• Protein Precursors (1973-1976)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Peptide Hydrolases
Endopeptidases
Metalloendopeptidases
Procollagen N-Endopeptidase

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Peptide Hydrolases
Metalloproteases
Metalloendopeptidases
Procollagen N-Endopeptidase