Phosphofructokinase-2
An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.
Year introduced: 2002
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Subheadings:
Tree Number(s): D08.811.277.352.650.622, D08.811.641.843, D08.811.913.696.620.225.850.750
MeSH Unique ID: D025481
Registry Number: EC 2.7.1.105
Entry Terms:
- Phosphofructokinase 2
- 6PF2K
- 6-Phosphofructo-2-kinase
- Fru-6-P,2-kinase
- Fructose-6-P,2-kinase
- Fructose-6-phosphate,2-kinase
- ATP-D-Fructose-6-phosphate 2-phosphotransferase
- Fructose-2,6-bisphosphatase
- Fructose 2,6-bisphosphatase
- fructose-2,6-diphosphatase
- Fructose-2,6-bisphosphate 2-phosphatase
- 6-Phosphofructo-2-kinase-fructose-2,6-bisphosphatase
- 6-PF-2-K-Fru-2,6-P(2)ase
- 6-Phosphofructo 2-kinase-fructose 2,6-bisphosphatase
- F Kinase-F-bisphosphatase
- Fru-kinase-Fru-bisphosphatase
- Fructose-6-phosphate,2-kinase-fructose-2,6-bisphosphatase
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