Sphingomyelin Phosphodiesterase

An enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide (N-acylsphingosine) plus choline phosphate. A defect in this enzyme leads to NIEMANN-PICK DISEASE. EC 3.1.4.12.

Year introduced: 1991(1975)

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Tree Number(s): D08.811.277.352.640.750

MeSH Unique ID: D013108

Registry Number: EC 3.1.4.12

Entry Terms:

• Sphingomyelin Cholinephosphohydrolase
• Sphingomyelin Cleaving Enzyme
• Sphingomyelinase
• Sphingomyelinase C

Previous Indexing:

• Phosphodiesterases (1973-1974)
• Sphingomyelins (1973-1974)

See Also:

• Niemann-Pick Diseases

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Esterases
Phosphoric Diester Hydrolases
Sphingomyelin Phosphodiesterase