Deoxyribonuclease I

An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.

Year introduced: 1985

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Tree Number(s): D08.811.277.352.335.350.250

MeSH Unique ID: D003850

Registry Number: EC 3.1.21.1

Entry Terms:

• DNase I
• Pancreatic DNase
• DNase, Pancreatic
• Thymonuclease
• DNAase I
• DNA Endonuclease
• Endonuclease, DNA
• Streptodornase
• T4-Endonuclease II
• T4 Endonuclease II
• Nickase
• DNA Nicking Enzyme
• Endonuclease I
• T7-Endonuclease I
• T7 Endonuclease I
• Dornavac

Previous Indexing:

• Deoxyribonucleases (1966-1982)
• Endodeoxyribonucleases (1983-1984)
• Endonucleases (1973-1982)

All MeSH Categories
Chemicals and Drugs Category
Enzymes and Coenzymes
Enzymes
Hydrolases
Esterases
Deoxyribonucleases
Endodeoxyribonucleases
Deoxyribonuclease I
Streptodornase and Streptokinase