DNA-(Apurinic or Apyrimidinic Site) Lyase
A DNA repair enzyme that catalyses the excision of ribose residues at apurinic and apyrimidinic DNA sites that can result from the action of DNA GLYCOSYLASES. The enzyme catalyzes a beta-elimination reaction in which the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. This enzyme was previously listed under EC 3.1.25.2.
Year introduced: 2004
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Subheadings:
Tree Number(s): D08.811.074.750, D08.811.520.241.225
MeSH Unique ID: D043603
Registry Number: EC 4.2.99.18
Entry Terms:
- DNA Lyase (Apurinic or Apyrimidinic)
- AP Endonuclease
- Endonuclease, AP
- AP Lyase
- Apurine-Apyrimidine Endonuclease
- Apurine Apyrimidine Endonuclease
- Endonuclease, Apurine-Apyrimidine
- Apurinic DNA Endonuclease
- DNA Endonuclease, Apurinic
- Endonuclease, Apurinic DNA
- Apurinic Endonuclease
- Endonuclease, Apurinic
- Endodeoxyribonuclease (Apurinic or Apyrimidinic)
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