Simvastatin

A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.

Year introduced: 1998

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Tree Number(s): D02.455.426.559.847.638.400.900, D04.615.638.400.900

MeSH Unique ID: D019821

Registry Number: AGG2FN16EV

Entry Terms:

• Zocor
• MK-733
• MK733
• MK 733
• Synvinolin

Previous Indexing:

• Lovastatin/analogs and derivatives (1988-1997)
• Naphthalenes (1986-1987)

See Also:

• Rosuvastatin Calcium

Pharmacologic Action:

• Anticholesteremic Agents
• Hypolipidemic Agents
• Hydroxymethylglutaryl-CoA Reductase Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Hydrocarbons
Hydrocarbons, Cyclic
Hydrocarbons, Aromatic
Polycyclic Aromatic Hydrocarbons
Naphthalenes
Lovastatin
Simvastatin
Ezetimibe, Simvastatin Drug Combination

All MeSH Categories
Chemicals and Drugs Category
Polycyclic Compounds
Polycyclic Aromatic Hydrocarbons
Naphthalenes
Lovastatin
Simvastatin
Ezetimibe, Simvastatin Drug Combination