Lovastatin

A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.

Year introduced: 1988

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Tree Number(s): D02.455.426.559.847.638.400, D04.615.638.400

MeSH Unique ID: D008148

Registry Number: 9LHU78OQFD

Entry Terms:

• 6-Methylcompactin
• 6 Methylcompactin
• Mevinolin
• Monacolin K
• Lovastatin, 1 alpha-Isomer
• 1 alpha-Isomer Lovastatin
• alpha-Isomer Lovastatin, 1
• Lovastatin, 1 alpha Isomer
• Lovastatin, (1 alpha(S*))-Isomer
• MK-803
• MK803
• MK 803
• Mevacor

Previous Indexing:

• Anticholesteremic Agents (1966-1987)
• Hydroxymethylglutaryl CoA Reductases/antagonists and inhibitors (1977-1987)
• Naphthalenes (1966-1987)

Pharmacologic Action:

• Anticholesteremic Agents
• Hydroxymethylglutaryl-CoA Reductase Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Organic Chemicals
Hydrocarbons
Hydrocarbons, Cyclic
Hydrocarbons, Aromatic
Polycyclic Aromatic Hydrocarbons
Naphthalenes
Lovastatin
Simvastatin
Ezetimibe, Simvastatin Drug Combination

All MeSH Categories
Chemicals and Drugs Category
Polycyclic Compounds
Polycyclic Aromatic Hydrocarbons
Naphthalenes
Lovastatin
Simvastatin
Ezetimibe, Simvastatin Drug Combination