Plicamycin
A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
Year introduced: 1993
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Subheadings:
Tree Number(s): D02.455.426.559.847.562.050.650, D04.615.562.050.650, D09.408.051.059.650
MeSH Unique ID: D008926
Registry Number: NIJ123W41V
Entry Terms:
- Aureolic Acid
- Mithramycin
- Mitramycin
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Pharmacologic Action: