Isaacs Syndrome
A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)
Year introduced: 2000
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Subheadings:
Tree Number(s): C05.651.392, C10.668.829.425
MeSH Unique ID: D020386
Entry Terms:
- Myokymia, Myotonia, Muscle Wasting, And Hyperhidrosis
- Continuous Muscle Activity Syndrome
- Gamstorp-Wohlfart Syndrome
- Gamstorp Wohlfart Syndrome
- Isaacs' Syndrome
- Isaac Syndrome
- Isaacs-Mertens Syndrome
- Isaacs Mertens Syndrome
- Myokymia, Continuous
- Continuous Myokymia
- Continuous Myokymias
- Myokymias, Continuous
- Neuromyotonia
- Pseudomyotonia Syndrome of Isaacs
- Isaacs Pseudomyotonia Syndrome
- Quantal Squander
- Syndrome of Continuous Muscle Activity
- Acquired Neuromyotonia
- Neuromyotonia, Acquired
- Pseudomyotonia
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