Giant Cells, Langhans

Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity.

Year introduced: 1991(1990)

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Tree Number(s): A11.329.372.380, A11.500.380, A11.627.482.380, A11.733.397.380, A15.382.670.522.380, A15.382.680.397.380

MeSH Unique ID: D015744

Entry Terms:

• Langhans-Type Giant Cells
• Cells, Langhans-Type Giant
• Giant Cells, Langhans-Type
• Langhans Type Giant Cells
• Langhans Giant Cells
• Cells, Langhans Giant

Previous Indexing:

• Granuloma, Giant Cell (1977-1989)
• Macrophages (1966-1989)

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Anatomy Category
Cells
Connective Tissue Cells
Macrophages
Giant Cells, Langhans

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Cells
Giant Cells
Giant Cells, Langhans

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Cells
Myeloid Cells
Macrophages
Giant Cells, Langhans

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Cells
Phagocytes
Macrophages
Giant Cells, Langhans

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Hemic and Immune Systems
Immune System
Mononuclear Phagocyte System
Macrophages
Giant Cells, Langhans

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Anatomy Category
Hemic and Immune Systems
Immune System
Phagocytes
Macrophages
Giant Cells, Langhans