Camptothecin

An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Year introduced: 1973

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Tree Number(s): D03.132.151

MeSH Unique ID: D002166

Registry Number: XT3Z54Z28A

Entry Terms:

• Camptothecine

Previous Indexing:

• Alkaloids (1966-1972)
• Antineoplastic Agents (1966-1972)

Pharmacologic Action:

• Antineoplastic Agents, Phytogenic
• Topoisomerase I Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Alkaloids
Camptothecin
Irinotecan
Topotecan