sulindac sulfone [Supplementary Concept]

inhibits K-ras-dependent cyclooxygenase-2; sulfated analog of indomethacin;; CP248 is an antineoplastic agent that fosters microtubule depolymerization; structure in first source

Date introduced: July 31, 1980

MeSH Unique ID: C025463

Registry Number: K619IIG2R9

Heading Mapped to:

• Sulindac/analogs and derivatives

Entry Terms:

• exisulind
• sulindac sulfone, (Z)-isomer
• 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfonyl)phenyl)methylene)-, (Z)-
• CP248
• CP 248
• OSIP 486823
• OSIP-486823
• OSIP486823
• Aptosyn
• FGN-1
• (5-fluoro-2-methyl-1-(3,4,5-trimethoxybenzylidene)-3-(N-benzyl)-indene)-acetamide

Pharmacologic Action:

• Antineoplastic Agents
• Anticarcinogenic Agents
• Cyclooxygenase Inhibitors