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Malignant Granulosa Cell Tumor

MedGen UID:
87235
•Concept ID:
C0334401
•
Neoplastic Process
Synonyms: Cancer of Granulosa Cells; Cancer, Granulosa Cell; Cancers, Granulosa Cell; Cell Cancer, Granulosa; Cell Cancers, Granulosa; Cells Cancer, Granulosa; Cells Cancers, Granulosa; Granulosa Cell Cancer; Granulosa Cell Cancers; Granulosa Cells Cancer; Granulosa Cells Cancers
SNOMED CT: Malignant granulosa cell tumor (18861007); Granulosa cell tumor, sarcomatoid (18861007); Granulosa cell tumor, malignant (18861007); Malignant adult granulosa cell tumor (18861007)

Definition

A granulosa cell tumor which has an aggressive clinical course and metastasizes to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Granulosa Cell Tumor

Professional guidelines

PubMed

Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment.
Melnik BC
Cells 2023 Nov 10;12(22) doi: 10.3390/cells12222600. PMID: 37998335Free PMC Article
Clinical outcomes of leuprolide acetate in the treatment of recurrent ovarian granulosa cell tumors.
Foster KI, Flores Legarreta A, Kamat R, Handley KF, Glassman D, How JA, Lawson BC, Westin SN, Ramondetta LM, Frumovitz M, Gershenson DM, Sood AK, Hillman RT
Am J Obstet Gynecol 2023 Jun;228(6):724.e1-724.e9. Epub 2023 Mar 11 doi: 10.1016/j.ajog.2023.02.029. PMID: 36907533Free PMC Article
Fertility sparing management and pregnancy in patients with granulosa cell tumour of the ovaries.
Iavazzo C, Gkegkes ID, Vrachnis N
J Obstet Gynaecol 2015 May;35(4):331-5. Epub 2014 Nov 10 doi: 10.3109/01443615.2014.968107. PMID: 25383508

Recent clinical studies

Diagnosis

Malignant granulosa cell tumor of testis with metastasis to liver: Case report and review of literature.
Bordiya S, Priyanka K, Garg D
Indian J Pathol Microbiol 2020 Jul-Sep;63(3):470-471. doi: 10.4103/IJPM.IJPM_436_18. PMID: 32769343
Staging ovarian cancer: role of imaging.
Coakley FV
Radiol Clin North Am 2002 May;40(3):609-36. doi: 10.1016/s0033-8389(01)00012-4. PMID: 12117196
Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival.
Matoska J, Ondrus D, Talerman A
Cancer 1992 Apr 1;69(7):1769-72. doi: 10.1002/1097-0142(19920401)69:7<1769::aid-cncr2820690719>3.0.co;2-v. PMID: 1551061
Human granulosa cell tumor: stimulation of steroidogenesis by gonadotropins in vitro.
Hahlin M, Crona N, Knutsson F, Janson PO
Gynecol Oncol 1991 Mar;40(3):201-6. doi: 10.1016/0090-8258(90)90278-s. PMID: 1849499
Malignant ovarian tumors in children and adolescents.
Raney RB Jr, Sinclair L, Uri A, Schnaufer L, Cooper A, Littman P
Cancer 1987 Mar 15;59(6):1214-20. doi: 10.1002/1097-0142(19870315)59:6<1214::aid-cncr2820590631>3.0.co;2-z. PMID: 3815296

Therapy

Malignant ovarian tumors in children and adolescents.
Raney RB Jr, Sinclair L, Uri A, Schnaufer L, Cooper A, Littman P
Cancer 1987 Mar 15;59(6):1214-20. doi: 10.1002/1097-0142(19870315)59:6<1214::aid-cncr2820590631>3.0.co;2-z. PMID: 3815296

Prognosis

Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival.
Matoska J, Ondrus D, Talerman A
Cancer 1992 Apr 1;69(7):1769-72. doi: 10.1002/1097-0142(19920401)69:7<1769::aid-cncr2820690719>3.0.co;2-v. PMID: 1551061

Clinical prediction guides

Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.
Schofield DE, Fletcher JA
Am J Pathol 1992 Dec;141(6):1265-9. PMID: 1466394Free PMC Article

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