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OVARIAN CANCER, EPITHELIAL, SOMATIC

MedGen UID:
358303
•Concept ID:
C1868358
•
Finding
OMIM®: 171834

Professional guidelines

PubMed

PARP inhibitors as single agents and in combination therapy: the most promising treatment strategies in clinical trials for BRCA-mutant ovarian and triple-negative breast cancers.
Luo L, Keyomarsi K
Expert Opin Investig Drugs 2022 Jun;31(6):607-631. Epub 2022 May 3 doi: 10.1080/13543784.2022.2067527. PMID: 35435784Free PMC Article
Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.
Kurnit KC, Fleming GF, Lengyel E
Obstet Gynecol 2021 Jan 1;137(1):108-121. doi: 10.1097/AOG.0000000000004173. PMID: 33278287Free PMC Article
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article

Recent clinical studies

Etiology

Single-cell transcriptomic analysis of endometriosis.
Fonseca MAS, Haro M, Wright KN, Lin X, Abbasi F, Sun J, Hernandez L, Orr NL, Hong J, Choi-Kuaea Y, Maluf HM, Balzer BL, Fishburn A, Hickey R, Cass I, Goodridge HS, Truong M, Wang Y, Pisarska MD, Dinh HQ, El-Naggar A, Huntsman DG, Anglesio MS, Goodman MT, Medeiros F, Siedhoff M, Lawrenson K
Nat Genet 2023 Feb;55(2):255-267. Epub 2023 Jan 9 doi: 10.1038/s41588-022-01254-1. PMID: 36624343Free PMC Article
Transcription factors in epithelial ovarian cancer: histotype-specific drivers and novel therapeutic targets.
Nameki R, Chang H, Reddy J, Corona RI, Lawrenson K
Pharmacol Ther 2021 Apr;220:107722. Epub 2020 Nov 1 doi: 10.1016/j.pharmthera.2020.107722. PMID: 33137377
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Treatment of recurrent ovarian cancer.
Pignata S, C Cecere S, Du Bois A, Harter P, Heitz F
Ann Oncol 2017 Nov 1;28(suppl_8):viii51-viii56. doi: 10.1093/annonc/mdx441. PMID: 29232464
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.
Swisher EM, Lin KK, Oza AM, Scott CL, Giordano H, Sun J, Konecny GE, Coleman RL, Tinker AV, O'Malley DM, Kristeleit RS, Ma L, Bell-McGuinn KM, Brenton JD, Cragun JM, Oaknin A, Ray-Coquard I, Harrell MI, Mann E, Kaufmann SH, Floquet A, Leary A, Harding TC, Goble S, Maloney L, Isaacson J, Allen AR, Rolfe L, Yelensky R, Raponi M, McNeish IA
Lancet Oncol 2017 Jan;18(1):75-87. Epub 2016 Nov 29 doi: 10.1016/S1470-2045(16)30559-9. PMID: 27908594

Diagnosis

Combination ATR (ceralasertib) and PARP (olaparib) Inhibitor (CAPRI) Trial in Acquired PARP Inhibitor-Resistant Homologous Recombination-Deficient Ovarian Cancer.
Wethington SL, Shah PD, Martin L, Tanyi JL, Latif N, Morgan M, Torigian DA, Rodriguez D, Smith SA, Dean E, Domchek SM, Drapkin R, Shih IM, Brown EJ, Hwang WT, Armstrong DK, Gaillard S, Giuntoli R, Simpkins F
Clin Cancer Res 2023 Aug 1;29(15):2800-2807. doi: 10.1158/1078-0432.CCR-22-2444. PMID: 37097611
Single-Cell Dissection of the Multiomic Landscape of High-Grade Serous Ovarian Cancer.
Wang Y, Xie H, Chang X, Hu W, Li M, Li Y, Liu H, Cheng H, Wang S, Zhou L, Shen D, Dou S, Ma R, Mao Y, Zhu H, Zhang X, Zheng Y, Ye X, Wen L, Kee K, Cui H, Tang F
Cancer Res 2022 Nov 2;82(21):3903-3916. doi: 10.1158/0008-5472.CAN-21-3819. PMID: 35969151Free PMC Article
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer.
Paffenholz SV, Salvagno C, Ho YJ, Limjoco M, Baslan T, Tian S, Kulick A, de Stanchina E, Wilkinson JE, Barriga FM, Zamarin D, Cubillos-Ruiz JR, Leibold J, Lowe SW
Proc Natl Acad Sci U S A 2022 Feb 1;119(5) doi: 10.1073/pnas.2117754119. PMID: 35082152Free PMC Article
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article

Therapy

Combination ATR (ceralasertib) and PARP (olaparib) Inhibitor (CAPRI) Trial in Acquired PARP Inhibitor-Resistant Homologous Recombination-Deficient Ovarian Cancer.
Wethington SL, Shah PD, Martin L, Tanyi JL, Latif N, Morgan M, Torigian DA, Rodriguez D, Smith SA, Dean E, Domchek SM, Drapkin R, Shih IM, Brown EJ, Hwang WT, Armstrong DK, Gaillard S, Giuntoli R, Simpkins F
Clin Cancer Res 2023 Aug 1;29(15):2800-2807. doi: 10.1158/1078-0432.CCR-22-2444. PMID: 37097611
PARP inhibitors as single agents and in combination therapy: the most promising treatment strategies in clinical trials for BRCA-mutant ovarian and triple-negative breast cancers.
Luo L, Keyomarsi K
Expert Opin Investig Drugs 2022 Jun;31(6):607-631. Epub 2022 May 3 doi: 10.1080/13543784.2022.2067527. PMID: 35435784Free PMC Article
Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.
Kurnit KC, Fleming GF, Lengyel E
Obstet Gynecol 2021 Jan 1;137(1):108-121. doi: 10.1097/AOG.0000000000004173. PMID: 33278287Free PMC Article
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article

Prognosis

PARP inhibitors as single agents and in combination therapy: the most promising treatment strategies in clinical trials for BRCA-mutant ovarian and triple-negative breast cancers.
Luo L, Keyomarsi K
Expert Opin Investig Drugs 2022 Jun;31(6):607-631. Epub 2022 May 3 doi: 10.1080/13543784.2022.2067527. PMID: 35435784Free PMC Article
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer.
Paffenholz SV, Salvagno C, Ho YJ, Limjoco M, Baslan T, Tian S, Kulick A, de Stanchina E, Wilkinson JE, Barriga FM, Zamarin D, Cubillos-Ruiz JR, Leibold J, Lowe SW
Proc Natl Acad Sci U S A 2022 Feb 1;119(5) doi: 10.1073/pnas.2117754119. PMID: 35082152Free PMC Article
Low-Grade Serous Ovarian Cancer: Current Treatment Paradigms and Future Directions.
Grisham RN, Iyer G
Curr Treat Options Oncol 2018 Sep 18;19(11):54. doi: 10.1007/s11864-018-0571-8. PMID: 30225651
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.
Swisher EM, Lin KK, Oza AM, Scott CL, Giordano H, Sun J, Konecny GE, Coleman RL, Tinker AV, O'Malley DM, Kristeleit RS, Ma L, Bell-McGuinn KM, Brenton JD, Cragun JM, Oaknin A, Ray-Coquard I, Harrell MI, Mann E, Kaufmann SH, Floquet A, Leary A, Harding TC, Goble S, Maloney L, Isaacson J, Allen AR, Rolfe L, Yelensky R, Raponi M, McNeish IA
Lancet Oncol 2017 Jan;18(1):75-87. Epub 2016 Nov 29 doi: 10.1016/S1470-2045(16)30559-9. PMID: 27908594
Homologous recombination deficiency and ovarian cancer.
Ledermann JA, Drew Y, Kristeleit RS
Eur J Cancer 2016 Jun;60:49-58. Epub 2016 Apr 9 doi: 10.1016/j.ejca.2016.03.005. PMID: 27065456

Clinical prediction guides

PARP inhibitors as single agents and in combination therapy: the most promising treatment strategies in clinical trials for BRCA-mutant ovarian and triple-negative breast cancers.
Luo L, Keyomarsi K
Expert Opin Investig Drugs 2022 Jun;31(6):607-631. Epub 2022 May 3 doi: 10.1080/13543784.2022.2067527. PMID: 35435784Free PMC Article
Senescence induction dictates response to chemo- and immunotherapy in preclinical models of ovarian cancer.
Paffenholz SV, Salvagno C, Ho YJ, Limjoco M, Baslan T, Tian S, Kulick A, de Stanchina E, Wilkinson JE, Barriga FM, Zamarin D, Cubillos-Ruiz JR, Leibold J, Lowe SW
Proc Natl Acad Sci U S A 2022 Feb 1;119(5) doi: 10.1073/pnas.2117754119. PMID: 35082152Free PMC Article
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.
Swisher EM, Lin KK, Oza AM, Scott CL, Giordano H, Sun J, Konecny GE, Coleman RL, Tinker AV, O'Malley DM, Kristeleit RS, Ma L, Bell-McGuinn KM, Brenton JD, Cragun JM, Oaknin A, Ray-Coquard I, Harrell MI, Mann E, Kaufmann SH, Floquet A, Leary A, Harding TC, Goble S, Maloney L, Isaacson J, Allen AR, Rolfe L, Yelensky R, Raponi M, McNeish IA
Lancet Oncol 2017 Jan;18(1):75-87. Epub 2016 Nov 29 doi: 10.1016/S1470-2045(16)30559-9. PMID: 27908594
Homologous recombination deficiency and ovarian cancer.
Ledermann JA, Drew Y, Kristeleit RS
Eur J Cancer 2016 Jun;60:49-58. Epub 2016 Apr 9 doi: 10.1016/j.ejca.2016.03.005. PMID: 27065456

Recent systematic reviews

The prevalence of mismatch repair deficiency in ovarian cancer: A systematic review and meta-analysis.
Atwal A, Snowsill T, Dandy MC, Krum T, Newton C, Evans DG, Crosbie EJ, Ryan NAJ
Int J Cancer 2022 Nov 1;151(9):1626-1639. Epub 2022 Jul 6 doi: 10.1002/ijc.34165. PMID: 35792468Free PMC Article
PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.
Tew WP, Lacchetti C, Ellis A, Maxian K, Banerjee S, Bookman M, Jones MB, Lee JM, Lheureux S, Liu JF, Moore KN, Muller C, Rodriguez P, Walsh C, Westin SN, Kohn EC
J Clin Oncol 2020 Oct 20;38(30):3468-3493. Epub 2020 Aug 13 doi: 10.1200/JCO.20.01924. PMID: 32790492Free PMC Article
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Konstantinopoulos PA, Norquist B, Lacchetti C, Armstrong D, Grisham RN, Goodfellow PJ, Kohn EC, Levine DA, Liu JF, Lu KH, Sparacio D, Annunziata CM
J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
BRCA1 Expression by Immunohistochemistry and Prognosis in Ovarian Cancer: A Systematic Review and Meta-Analysis.
Teixeira LA, Candido Dos Reis FJ
Target Oncol 2020 Feb;15(1):37-46. doi: 10.1007/s11523-020-00697-y. PMID: 31960278
Somatic mutations in breast and serous ovarian cancer young patients: a systematic review and meta-analysis.
Encinas G, Maistro S, Pasini FS, Katayama ML, Brentani MM, Bock GH, Folgueira MA
Rev Assoc Med Bras (1992) 2015 Sep-Oct;61(5):474-83. doi: 10.1590/1806-9282.61.05.474. PMID: 26603012

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