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Ovarian Steroid Cell Tumor, Not Otherwise Specified

MedGen UID:
309518
Concept ID:
C1518740
Neoplastic Process
Synonym: Ovarian Steroid Cell Tumor, NOS

Definition

A steroid cell tumor that arises from the ovary and is defined by morphologic features that do not fit into the categories of Leydig cell tumor and stromal luteoma. These features include solid proliferations of polygonal neoplastic cells with eosinophilic and granular cytoplasm. Grossly, these tumors usually present as large and well circumscribed masses and are usually associated with androgenic manifestations. Approximately one third of the cases have a malignant clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Steroid Cell Tumor, Not Otherwise Specified

Professional guidelines

PubMed

Gompel A
Climacteric 2023 Jun;26(3):240-247. Epub 2023 Apr 3 doi: 10.1080/13697137.2023.2176216. PMID: 37011657
Mamoojee Y, Ganguri M, Taylor N, Quinton R
Clin Endocrinol (Oxf) 2018 Jan;88(1):13-20. Epub 2017 Nov 7 doi: 10.1111/cen.13492. PMID: 28980338
Dewailly D, Andersen CY, Balen A, Broekmans F, Dilaver N, Fanchin R, Griesinger G, Kelsey TW, La Marca A, Lambalk C, Mason H, Nelson SM, Visser JA, Wallace WH, Anderson RA
Hum Reprod Update 2014 May-Jun;20(3):370-85. Epub 2014 Jan 14 doi: 10.1093/humupd/dmt062. PMID: 24430863

Recent clinical studies

Etiology

Lin M, Bao K, Lu L, Xu S, Liang Y, Cheng X, Wang F
BMC Endocr Disord 2022 Nov 1;22(1):265. doi: 10.1186/s12902-022-01170-9. PMID: 36316664Free PMC Article
Jiang MJ, Le Q, Yang BW, Yuan F, Chen H
J Ovarian Res 2021 Apr 17;14(1):53. doi: 10.1186/s13048-021-00805-0. PMID: 33865445Free PMC Article
Haroon S, Idrees R, Fatima S, Memon A, Kayani N
J Obstet Gynaecol Res 2015 Mar;41(3):424-31. Epub 2014 Oct 27 doi: 10.1111/jog.12537. PMID: 25345475
Deavers MT, Malpica A, Ordonez NG, Silva EG
Int J Gynecol Pathol 2003 Apr;22(2):162-7. doi: 10.1097/00004347-200304000-00008. PMID: 12649671
Hayes MC, Scully RE
Am J Surg Pathol 1987 Nov;11(11):835-45. doi: 10.1097/00000478-198711000-00002. PMID: 2823622

Diagnosis

Chao A, Huang HJ, Lin CY, Lee CH, Lin CH, Chao AS, Lai CH, Chang TC, Wu KY, Wu RC
Endocr Relat Cancer 2023 Nov 1;30(11) Epub 2023 Oct 4 doi: 10.1530/ERC-23-0179. PMID: 37655726
Matemanosak P, Peeyananjarassri K, Suwanrath C, Wattanakumtornkul S, Klangsin S, Thiangphak E, Kanjanapradit K
Gynecol Endocrinol 2023 Dec;39(1):2186138. Epub 2023 Mar 6 doi: 10.1080/09513590.2023.2186138. PMID: 36878245
Lobaton-Ginsberg M, Malanco-Hernández LM, Ferreira-Hermosillo A
J Med Case Rep 2022 Dec 24;16(1):478. doi: 10.1186/s13256-022-03697-w. PMID: 36564842Free PMC Article
Mizoguchi M, Minami S, Yamamoto M, Tanizaki Y, Kobayashi A, Ino K
J Obstet Gynaecol Res 2014 Sep;40(9):2081-5. doi: 10.1111/jog.12467. PMID: 25181629
Thomas TT, Ruscher KR, Mandavilli S, Balarezo F, Finck CM
J Pediatr Surg 2013 Jun;48(6):E23-7. doi: 10.1016/j.jpedsurg.2013.04.006. PMID: 23845653

Therapy

Terada KY, Ahn HJ, Kessel B
J Gynecol Oncol 2016 May;27(3):e25. doi: 10.3802/jgo.2016.27.e25. PMID: 27029746Free PMC Article
Baş F, Saka N, Darendeliler F, Tuzlali S, Ilhan R, Bundak R, Günöz H
J Pediatr Endocrinol Metab 2000 Jun;13(6):663-7. doi: 10.1515/jpem.2000.13.6.663. PMID: 10905393
Brewer CA, Shevlin D
Obstet Gynecol 1998 Oct;92(4 Pt 2):661-3. doi: 10.1016/s0029-7844(98)00166-5. PMID: 9764654
Wang PH, Chao HT, Lee WL
Fertil Steril 1998 Feb;69(2):353-5. doi: 10.1016/s0015-0282(97)00500-1. PMID: 9496356

Prognosis

Lin M, Bao K, Lu L, Xu S, Liang Y, Cheng X, Wang F
BMC Endocr Disord 2022 Nov 1;22(1):265. doi: 10.1186/s12902-022-01170-9. PMID: 36316664Free PMC Article
Jiang MJ, Le Q, Yang BW, Yuan F, Chen H
J Ovarian Res 2021 Apr 17;14(1):53. doi: 10.1186/s13048-021-00805-0. PMID: 33865445Free PMC Article
Vasilevska D, Rudaitis V, Vasilevska D, Mickys U, Wawrysiuk S, Semczuk A
J Int Med Res 2021 Jan;49(1):300060520983195. doi: 10.1177/0300060520983195. PMID: 33435776Free PMC Article
Hasegawa K, Minami Y, Inuzuka H, Oe S, Kato R, Tsukada K, Udagawa Y, Kuroda M
Clin Exp Obstet Gynecol 2013;40(4):591-5. PMID: 24597265
Hayes MC, Scully RE
Am J Surg Pathol 1987 Nov;11(11):835-45. doi: 10.1097/00000478-198711000-00002. PMID: 2823622

Clinical prediction guides

Umeda S, Takase K, Takayama K, Yamamichi T, Higuchi K, Kawai M, Takeuchi M, Inoue M, Usui N
J Pediatr Hematol Oncol 2023 May 1;45(4):e522-e524. Epub 2022 Jun 7 doi: 10.1097/MPH.0000000000002496. PMID: 35700385
Lin M, Bao K, Lu L, Xu S, Liang Y, Cheng X, Wang F
BMC Endocr Disord 2022 Nov 1;22(1):265. doi: 10.1186/s12902-022-01170-9. PMID: 36316664Free PMC Article
Jiang MJ, Le Q, Yang BW, Yuan F, Chen H
J Ovarian Res 2021 Apr 17;14(1):53. doi: 10.1186/s13048-021-00805-0. PMID: 33865445Free PMC Article
Matsukawa J, Takahashi T, Hada Y, Kameda W, Ota K, Fukase M, Takahashi K, Matsuo K, Mizunuma H, Nagase S
Fukushima J Med Sci 2020 Jan 9;65(3):133-139. Epub 2019 Dec 11 doi: 10.5387/fms.2019-25. PMID: 31827013Free PMC Article
Haroon S, Idrees R, Fatima S, Memon A, Kayani N
J Obstet Gynaecol Res 2015 Mar;41(3):424-31. Epub 2014 Oct 27 doi: 10.1111/jog.12537. PMID: 25345475

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