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Ovarian endometrial cancer

MedGen UID:
276545
•Concept ID:
C1518231
•
Neoplastic Process
Synonyms: endometrioid neoplasm of ovary; endometrioid tumor of ovary; endometrioid tumour of ovary; Malignant Ovarian Endometrioid Tumor; malignant ovarian endometrioid tumor; malignant ovarian endometrioid tumour; ovarian endometrial cancer; ovarian endometrioid neoplasm; ovary endometrioid tumor; ovary endometrioid tumour; ovary female reproductive endometrioid cancer
 
Monarch Initiative: MONDO:0003812

Definition

An invasive malignant neoplasm that arises from the ovary characterized by the presence of malignant, endometrial-type cells. It includes endometrioid adenocarcinoma and carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Genetically predicted serum testosterone and risk of gynecological disorders: a Mendelian randomization study.
Zhao B, Wang Z, Liu D, Zhang S
Front Endocrinol (Lausanne) 2023;14:1161356. Epub 2023 Nov 21 doi: 10.3389/fendo.2023.1161356. PMID: 38075074Free PMC Article
Dostarlimab as a Miracle Drug: Rising Hope against Cancer Treatment.
Singh V, Sheikh A, Abourehab MAS, Kesharwani P
Biosensors (Basel) 2022 Aug 8;12(8) doi: 10.3390/bios12080617. PMID: 36005013Free PMC Article
Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition.
Vitale SG, Capriglione S, Zito G, Lopez S, Gulino FA, Di Guardo F, Vitagliano A, Noventa M, La Rosa VL, Sapia F, Valenti G, Rapisarda AMC, Peterlunger I, Rossetti D, Laganà AS
Arch Gynecol Obstet 2019 Feb;299(2):299-315. Epub 2018 Dec 12 doi: 10.1007/s00404-018-5006-z. PMID: 30542793

Curated

UK NICE Diagnostics Guidance DG42, Testing strategies for Lynch syndrome in people with endometrial cancer, 2020

Recent clinical studies

Etiology

Oral Contraceptive Use in BRCA1 and BRCA2 Mutation Carriers: Absolute Cancer Risks and Benefits.
Schrijver LH, Mooij TM, Pijpe A, Sonke GS, Mourits MJE, Andrieu N, Antoniou AC, Easton DF, Engel C, Goldgar D, John EM, Kast K, Milne RL, Olsson H, Phillips KA, Terry MB, Hopper JL, van Leeuwen FE, Rookus MA
J Natl Cancer Inst 2022 Apr 11;114(4):540-552. doi: 10.1093/jnci/djac004. PMID: 35048954Free PMC Article
Myometrial Responses to Beta-Adrenoceptor Antagonists in Gynecological Malignancies.
Modzelewska B, Jóźwik M, Kleszczewski T, Sulkowski S, Jóźwik M
Gynecol Obstet Invest 2021;86(1-2):162-169. Epub 2021 Feb 26 doi: 10.1159/000513718. PMID: 33640886
Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women's Health Initiative Observational Study.
Trabert B, Coburn SB, Falk RT, Manson JE, Brinton LA, Gass ML, Kuller LH, Rohan TE, Pfeiffer RM, Qi L, Stefanick ML, Wentzensen N, Anderson GL, Xu X
Cancer Causes Control 2019 Nov;30(11):1201-1211. Epub 2019 Sep 21 doi: 10.1007/s10552-019-01233-8. PMID: 31542834Free PMC Article
Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study.
Playdon MC, Coburn SB, Moore SC, Brinton LA, Wentzensen N, Anderson G, Wallace R, Falk RT, Pfeiffer R, Xu X, Trabert B
Br J Cancer 2018 Feb 6;118(3):448-457. Epub 2017 Dec 12 doi: 10.1038/bjc.2017.419. PMID: 29235567Free PMC Article
Altered uterine contractility in response to β-adrenoceptor agonists in ovarian cancer.
Modzelewska B, Jóźwik M, Jóźwik M, Sulkowski S, Pędzińska-Betiuk A, Kleszczewski T, Kostrzewska A
J Physiol Sci 2017 Nov;67(6):711-722. Epub 2016 Nov 12 doi: 10.1007/s12576-016-0500-1. PMID: 27838886Free PMC Article

Diagnosis

Mismatch-repair deficiency, microsatellite instability, and lynch syndrome in ovarian cancer: A systematic review and meta-analysis.
Mitric C, Salman L, Abrahamyan L, Kim SR, Pechlivanoglou P, Chan KKW, Gien LT, Ferguson SE
Gynecol Oncol 2023 Mar;170:133-142. Epub 2023 Jan 20 doi: 10.1016/j.ygyno.2022.12.008. PMID: 36682091
Alcohol and oestrogen metabolites in postmenopausal women in the Women's Health Initiative Observational Study.
Playdon MC, Coburn SB, Moore SC, Brinton LA, Wentzensen N, Anderson G, Wallace R, Falk RT, Pfeiffer R, Xu X, Trabert B
Br J Cancer 2018 Feb 6;118(3):448-457. Epub 2017 Dec 12 doi: 10.1038/bjc.2017.419. PMID: 29235567Free PMC Article
Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer.
Ramus SJ, Elmasry K, Luo Z, Gammerman A, Lu K, Ayhan A, Singh N, McCluggage WG, Jacobs IJ, Whittaker JC, Gayther SA
Clin Cancer Res 2008 Sep 15;14(18):5840-8. doi: 10.1158/1078-0432.CCR-08-0373. PMID: 18794095

Therapy

Aromatase inhibitors: possible future applications.
Karaer O, Oruç S, Koyuncu FM
Acta Obstet Gynecol Scand 2004 Aug;83(8):699-706. doi: 10.1111/j.0001-6349.2004.00562.x. PMID: 15255840

Prognosis

Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer.
Ramus SJ, Elmasry K, Luo Z, Gammerman A, Lu K, Ayhan A, Singh N, McCluggage WG, Jacobs IJ, Whittaker JC, Gayther SA
Clin Cancer Res 2008 Sep 15;14(18):5840-8. doi: 10.1158/1078-0432.CCR-08-0373. PMID: 18794095
Aromatase inhibitors: possible future applications.
Karaer O, Oruç S, Koyuncu FM
Acta Obstet Gynecol Scand 2004 Aug;83(8):699-706. doi: 10.1111/j.0001-6349.2004.00562.x. PMID: 15255840

Clinical prediction guides

Myometrial Responses to Beta-Adrenoceptor Antagonists in Gynecological Malignancies.
Modzelewska B, Jóźwik M, Kleszczewski T, Sulkowski S, Jóźwik M
Gynecol Obstet Invest 2021;86(1-2):162-169. Epub 2021 Feb 26 doi: 10.1159/000513718. PMID: 33640886
Circulating estrogens and postmenopausal ovarian and endometrial cancer risk among current hormone users in the Women's Health Initiative Observational Study.
Trabert B, Coburn SB, Falk RT, Manson JE, Brinton LA, Gass ML, Kuller LH, Rohan TE, Pfeiffer RM, Qi L, Stefanick ML, Wentzensen N, Anderson GL, Xu X
Cancer Causes Control 2019 Nov;30(11):1201-1211. Epub 2019 Sep 21 doi: 10.1007/s10552-019-01233-8. PMID: 31542834Free PMC Article
Altered uterine contractility in response to β-adrenoceptor agonists in ovarian cancer.
Modzelewska B, Jóźwik M, Jóźwik M, Sulkowski S, Pędzińska-Betiuk A, Kleszczewski T, Kostrzewska A
J Physiol Sci 2017 Nov;67(6):711-722. Epub 2016 Nov 12 doi: 10.1007/s12576-016-0500-1. PMID: 27838886Free PMC Article
Predicting clinical outcome in patients diagnosed with synchronous ovarian and endometrial cancer.
Ramus SJ, Elmasry K, Luo Z, Gammerman A, Lu K, Ayhan A, Singh N, McCluggage WG, Jacobs IJ, Whittaker JC, Gayther SA
Clin Cancer Res 2008 Sep 15;14(18):5840-8. doi: 10.1158/1078-0432.CCR-08-0373. PMID: 18794095
Aromatase inhibitors: possible future applications.
Karaer O, Oruç S, Koyuncu FM
Acta Obstet Gynecol Scand 2004 Aug;83(8):699-706. doi: 10.1111/j.0001-6349.2004.00562.x. PMID: 15255840

Recent systematic reviews

Mismatch-repair deficiency, microsatellite instability, and lynch syndrome in ovarian cancer: A systematic review and meta-analysis.
Mitric C, Salman L, Abrahamyan L, Kim SR, Pechlivanoglou P, Chan KKW, Gien LT, Ferguson SE
Gynecol Oncol 2023 Mar;170:133-142. Epub 2023 Jan 20 doi: 10.1016/j.ygyno.2022.12.008. PMID: 36682091

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    Curated

    • NICE, 2020
      UK NICE Diagnostics Guidance DG42, Testing strategies for Lynch syndrome in people with endometrial cancer, 2020

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
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      Related literature resources in PubMed

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