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Borderline Ovarian Clear Cell Tumor

MedGen UID:
267394
•Concept ID:
C1511261
•
Neoplastic Process
Synonym: Borderline Ovarian Clear Cell Neoplasm

Definition

An epithelial neoplasm with low malignant potential affecting the ovary. It is characterized by the presence of clear or hobnail cells. In some cases, the cells may display nuclear atypia and prominent nucleoli. When such cells are present, they remain confined to the glands. There is no evidence of stromal invasion. [from NCI]

Professional guidelines

PubMed

Clear Cell Borderline Ovarian Tumor: Clinical Characteristics, Prognosis, and Management.
Ricotta G, Maulard A, Candiani M, Genestie C, Pautier P, Leary A, Chargari C, Mangili G, Morice P, Gouy S
Ann Surg Oncol 2022 Feb;29(2):1165-1170. Epub 2021 Oct 1 doi: 10.1245/s10434-021-10776-7. PMID: 34596794

Recent clinical studies

Etiology

Clear Cell Borderline Ovarian Tumor: Clinical Characteristics, Prognosis, and Management.
Ricotta G, Maulard A, Candiani M, Genestie C, Pautier P, Leary A, Chargari C, Mangili G, Morice P, Gouy S
Ann Surg Oncol 2022 Feb;29(2):1165-1170. Epub 2021 Oct 1 doi: 10.1245/s10434-021-10776-7. PMID: 34596794
Brenner Borderline Ovarian Tumor: A Case Series and Literature Review.
Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S
Ann Surg Oncol 2021 Oct;28(11):6714-6720. Epub 2021 Mar 25 doi: 10.1245/s10434-021-09879-y. PMID: 33768396
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Ovarian cancer: epidemiology and risk factors.
La Vecchia C
Eur J Cancer Prev 2017 Jan;26(1):55-62. doi: 10.1097/CEJ.0000000000000217. PMID: 26731563
The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.
Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587Free PMC Article

Diagnosis

Ovarian Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Armstrong DK, Alvarez RD, Bakkum-Gamez JN, Barroilhet L, Behbakht K, Berchuck A, Chen LM, Cristea M, DeRosa M, Eisenhauer EL, Gershenson DM, Gray HJ, Grisham R, Hakam A, Jain A, Karam A, Konecny GE, Leath CA, Liu J, Mahdi H, Martin L, Matei D, McHale M, McLean K, Miller DS, O'Malley DM, Percac-Lima S, Ratner E, Remmenga SW, Vargas R, Werner TL, Zsiros E, Burns JL, Engh AM
J Natl Compr Canc Netw 2021 Feb 2;19(2):191-226. doi: 10.6004/jnccn.2021.0007. PMID: 33545690
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307
Ovarian cancer: epidemiology and risk factors.
La Vecchia C
Eur J Cancer Prev 2017 Jan;26(1):55-62. doi: 10.1097/CEJ.0000000000000217. PMID: 26731563

Therapy

Ovarian cancer: epidemiology and risk factors.
La Vecchia C
Eur J Cancer Prev 2017 Jan;26(1):55-62. doi: 10.1097/CEJ.0000000000000217. PMID: 26731563
Cancerous ovarian stem cells: obscure targets for therapy but relevant to chemoresistance.
Ahmed N, Abubaker K, Findlay J, Quinn M
J Cell Biochem 2013 Jan;114(1):21-34. doi: 10.1002/jcb.24317. PMID: 22887554
Alcohol drinking and epithelial ovarian cancer risk. a systematic review and meta-analysis.
Rota M, Pasquali E, Scotti L, Pelucchi C, Tramacere I, Islami F, Negri E, Boffetta P, Bellocco R, Corrao G, La Vecchia C, Bagnardi V
Gynecol Oncol 2012 Jun;125(3):758-63. Epub 2012 Mar 23 doi: 10.1016/j.ygyno.2012.03.031. PMID: 22449732
Clinicopathological characteristics of ovarian carcinomas associated with endometriosis.
Kondi-Pafiti A, Papakonstantinou E, Iavazzo C, Grigoriadis C, Salakos N, Gregoriou O
Arch Gynecol Obstet 2012 Feb;285(2):479-83. Epub 2011 Jun 30 doi: 10.1007/s00404-011-1957-z. PMID: 21717140
Pathogenesis of ovarian cancer: lessons from morphology and molecular biology and their clinical implications.
Kurman RJ, Shih IeM
Int J Gynecol Pathol 2008 Apr;27(2):151-60. doi: 10.1097/PGP.0b013e318161e4f5. PMID: 18317228Free PMC Article

Prognosis

Clear Cell Borderline Ovarian Tumor: Clinical Characteristics, Prognosis, and Management.
Ricotta G, Maulard A, Candiani M, Genestie C, Pautier P, Leary A, Chargari C, Mangili G, Morice P, Gouy S
Ann Surg Oncol 2022 Feb;29(2):1165-1170. Epub 2021 Oct 1 doi: 10.1245/s10434-021-10776-7. PMID: 34596794
Brenner Borderline Ovarian Tumor: A Case Series and Literature Review.
Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S
Ann Surg Oncol 2021 Oct;28(11):6714-6720. Epub 2021 Mar 25 doi: 10.1245/s10434-021-09879-y. PMID: 33768396
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Pathology of borderline and invasive cancers.
Prat J
Best Pract Res Clin Obstet Gynaecol 2017 May;41:15-30. Epub 2016 Oct 3 doi: 10.1016/j.bpobgyn.2016.08.007. PMID: 28277307

Clinical prediction guides

MRI of Borderline Epithelial Ovarian Tumors: Pathologic Correlation and Diagnostic Challenges.
Tsuboyama T, Sato K, Ota T, Fukui H, Onishi H, Nakamoto A, Tatsumi M, Tomiyama N
Radiographics 2022 Nov-Dec;42(7):2095-2111. Epub 2022 Sep 9 doi: 10.1148/rg.220068. PMID: 36083804
Clear Cell Borderline Ovarian Tumor: Clinical Characteristics, Prognosis, and Management.
Ricotta G, Maulard A, Candiani M, Genestie C, Pautier P, Leary A, Chargari C, Mangili G, Morice P, Gouy S
Ann Surg Oncol 2022 Feb;29(2):1165-1170. Epub 2021 Oct 1 doi: 10.1245/s10434-021-10776-7. PMID: 34596794
Brenner Borderline Ovarian Tumor: A Case Series and Literature Review.
Ricotta G, Maulard A, Genestie C, Pautier P, Leary A, Chargari C, Candiani M, Morice P, Gouy S
Ann Surg Oncol 2021 Oct;28(11):6714-6720. Epub 2021 Mar 25 doi: 10.1245/s10434-021-09879-y. PMID: 33768396
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
TP53 and ovarian cancer.
Schuijer M, Berns EM
Hum Mutat 2003 Mar;21(3):285-91. doi: 10.1002/humu.10181. PMID: 12619114

Recent systematic reviews

Outcomes after Fertility-sparing Surgery for Women with Ovarian Cancer: A Systematic Review of the Literature.
Bercow A, Nitecki R, Brady PC, Rauh-Hain JA
J Minim Invasive Gynecol 2021 Mar;28(3):527-536.e1. Epub 2020 Aug 26 doi: 10.1016/j.jmig.2020.08.018. PMID: 32861046
Dose-risk relationships between cigarette smoking and ovarian cancer histotypes: a comprehensive meta-analysis.
Santucci C, Bosetti C, Peveri G, Liu X, Bagnardi V, Specchia C, Gallus S, Lugo A
Cancer Causes Control 2019 Sep;30(9):1023-1032. Epub 2019 Jun 24 doi: 10.1007/s10552-019-01198-8. PMID: 31236793
Fertility-sparing surgery in epithelial ovarian cancer: a systematic review of oncological issues.
Bentivegna E, Gouy S, Maulard A, Pautier P, Leary A, Colombo N, Morice P
Ann Oncol 2016 Nov;27(11):1994-2004. Epub 2016 Aug 8 doi: 10.1093/annonc/mdw311. PMID: 27502723
Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options.
Daraï E, Fauvet R, Uzan C, Gouy S, Duvillard P, Morice P
Hum Reprod Update 2013 Mar-Apr;19(2):151-66. Epub 2012 Dec 12 doi: 10.1093/humupd/dms047. PMID: 23242913
Alcohol drinking and epithelial ovarian cancer risk. a systematic review and meta-analysis.
Rota M, Pasquali E, Scotti L, Pelucchi C, Tramacere I, Islami F, Negri E, Boffetta P, Bellocco R, Corrao G, La Vecchia C, Bagnardi V
Gynecol Oncol 2012 Jun;125(3):758-63. Epub 2012 Mar 23 doi: 10.1016/j.ygyno.2012.03.031. PMID: 22449732

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