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Malignant Ovarian Luteinized Thecoma

MedGen UID:
233666
•Concept ID:
C1334608
•
Neoplastic Process
Synonyms: Malignant Luteinized Thecal Cell Neoplasm of Ovary; Malignant Luteinized Thecal Cell Neoplasm of the Ovary; Malignant Luteinized Thecal Cell Tumor of Ovary; Malignant Luteinized Thecal Cell Tumor of the Ovary; Malignant Luteinized Thecoma of Ovary; Malignant Luteinized Thecoma of the Ovary; Malignant Ovarian Luteinized Thecal Cell Neoplasm; Malignant Ovarian Luteinized Thecal Cell Tumor

Definition

A thecoma of the ovary that contains lutein cells and may metastasize to other anatomic sites. It is usually characterized by nuclear atypia and mitotic activity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Ovarian Luteinized Thecoma

Professional guidelines

PubMed

Luteinized thecomatosis and other conditions associated with sclerosing peritonitis: a problem in causation, management, and nomenclature.
Roth LM
Expert Rev Anticancer Ther 2021 Mar;21(3):239-240. Epub 2020 Dec 8 doi: 10.1080/14737140.2021.1853530. PMID: 33290110

Recent clinical studies

Etiology

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis.
Sharabidze N, Burkadze G, Sabakhtarashvili M
Georgian Med News 2006 Feb;(131):33-7. PMID: 16575127
Luteinizing hormone in peritoneal and ovarian cyst fluids: a predictor of ovarian carcinoma.
Halperin R, Pansky M, Vaknin Z, Zehavi S, Bukovsky I, Schneider D; Sackler Faculty of Medicine, Tel Aviv University, Israel
Eur J Obstet Gynecol Reprod Biol 2003 Oct 10;110(2):207-10. doi: 10.1016/s0301-2115(03)00122-2. PMID: 12969585
Luteinized thecoma with sclerosing peritonitis.
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912

Diagnosis

Pathological discrimination between luteinized thecoma associated with sclerosing peritonitis and thecoma.
Liu J, Wei J, Yang Y, Wei J
Medicine (Baltimore) 2023 Jun 9;102(23):e33911. doi: 10.1097/MD.0000000000033911. PMID: 37335673Free PMC Article
Adolescent ovarian thecoma presenting as progressive hyperandrogenism: case report and review of the literature.
Gaspari L, Paris F, Taourel P, Soyer-Gobillard MO, Kalfa N, Sultan C
Gynecol Endocrinol 2020 Sep;36(9):839-842. Epub 2020 Mar 16 doi: 10.1080/09513590.2020.1739265. PMID: 32174224
Luteinized Fibrothecoma.
Haghayeghi K, Hansen K, Quddus MR
Int J Surg Pathol 2019 Sep;27(6):654-655. Epub 2018 Dec 6 doi: 10.1177/1066896918817372. PMID: 30520326
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Selected topics in peritoneal pathology.
Baker PM, Clement PB, Young RH
Int J Gynecol Pathol 2014 Jul;33(4):393-401. doi: 10.1097/PGP.0000000000000146. PMID: 24901399

Therapy

Luteinized Thecomas ("Thecomatosis") with Sclerosing Peritonitis (LTSP): Report of 2 Cases and Review of an Enigmatic Syndrome Associated with a Peritoneal Proliferation of Specialized (vimentin+/keratin+/CD34+) Submesothelial Fibroblasts.
Altman AD, Bentley JR, Rittenberg PV, Murray SK
J Obstet Gynaecol Can 2016 Jan;38(1):41-50. doi: 10.1016/j.jogc.2015.10.010. PMID: 26872755
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
Sclerosing peritonitis associated with bilateral luteinized thecoma, linked to anticonvulsant therapy.
Levavi H, Sabah G, Heifetz M, Feinmesser M
Eur J Gynaecol Oncol 2009;30(6):695-700. PMID: 20099509
Luteinized thecoma associated with sclerosing peritonitis--conservative surgical approach followed by corticosteroid and GnRH agonist treatment--a case report.
Schonman R, Klein Z, Edelstein E, Czernobilsky B, Fishman A
Gynecol Oncol 2008 Dec;111(3):540-3. Epub 2008 May 29 doi: 10.1016/j.ygyno.2008.04.014. PMID: 18511110
Ovarian luteinized thecoma with sclerosing peritonitis in an adult woman treated with leuprolide and toremifene in complete remission at 5 years.
Bianco R, de Rosa G, Staibano S, Somma P, Bianco AR
Gynecol Oncol 2005 Mar;96(3):846-9. doi: 10.1016/j.ygyno.2004.10.044. PMID: 15721435

Prognosis

Granulosa Cell Tumors of the Ovary With Prominent Thecoma-like Foci: A Report of 16 Cases Emphasizing the Ongoing Utility of the Reticulin Stain in the Modern Era.
Stall JN, Young RH
Int J Gynecol Pathol 2019 Mar;38(2):143-150. doi: 10.1097/PGP.0000000000000508. PMID: 29708950
Fatal case of luteinized thecoma with sclerosing peritonitis in a 40-year-old woman.
Bahar B, Hu Z, Szpaderska A, Liotta M, Potkul RK, Smith D, Erşahin Ç
Int J Gynecol Pathol 2014 Jan;33(1):30-4. doi: 10.1097/PGP.0b013e31827d1a65. PMID: 24300532
Luteinizing hormone in peritoneal and ovarian cyst fluids: a predictor of ovarian carcinoma.
Halperin R, Pansky M, Vaknin Z, Zehavi S, Bukovsky I, Schneider D; Sackler Faculty of Medicine, Tel Aviv University, Israel
Eur J Obstet Gynecol Reprod Biol 2003 Oct 10;110(2):207-10. doi: 10.1016/s0301-2115(03)00122-2. PMID: 12969585
Granulosa and theca cell tumors in children: a report of 17 cases and literature review.
Cronjé HS, Niemand I, Bam RH, Woodruff JD
Obstet Gynecol Surv 1998 Apr;53(4):240-7. doi: 10.1097/00006254-199804000-00022. PMID: 9560834
Luteinized thecoma with sclerosing peritonitis.
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912

Clinical prediction guides

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
On the pathogenesis of sclerosing stromal tumor of the ovary: a neoplasm in transition.
Roth LM, Gaba AR, Cheng L
Int J Gynecol Pathol 2014 Sep;33(5):449-62. doi: 10.1097/PGP.0000000000000084. PMID: 25083960
Involuting luteinized thecoma of the ovary.
Roth LM, Gaba AR, Linden MD, Sandusky GE
Int J Gynecol Pathol 2014 Jan;33(1):23-9. doi: 10.1097/PGP.0b013e31827db06f. PMID: 24300531
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
Luteinizing hormone in peritoneal and ovarian cyst fluids: a predictor of ovarian carcinoma.
Halperin R, Pansky M, Vaknin Z, Zehavi S, Bukovsky I, Schneider D; Sackler Faculty of Medicine, Tel Aviv University, Israel
Eur J Obstet Gynecol Reprod Biol 2003 Oct 10;110(2):207-10. doi: 10.1016/s0301-2115(03)00122-2. PMID: 12969585

Recent systematic reviews

Luteinized thecoma (thecomatosis) with sclerosing peritonitis: a systematic review of the literature of the last 25 years.
Muratori L, Trevisi E, Delcuratolo MD, Sperone P, Di Maio M
Expert Rev Anticancer Ther 2021 Jan;21(1):23-32. Epub 2020 Oct 22 doi: 10.1080/14737140.2021.1837629. PMID: 33053314

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