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Borderline Ovarian Mucinous Tumor/Atypical Proliferative Ovarian Mucinous Tumor with Microinvasion

MedGen UID:
1707329
•Concept ID:
C5204343
•
Neoplastic Process

Definition

A low grade ovarian epithelial neoplasm characterized by the presence of neoplastic mucinous epithelial cells, atypia, and microinvasion of the ovarian stroma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorderline Ovarian Mucinous Tumor/Atypical Proliferative Ovarian Mucinous Tumor with Microinvasion

Professional guidelines

PubMed

Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior.
Ronnett BM, Kajdacsy-Balla A, Gilks CB, Merino MJ, Silva E, Werness BA, Young RH
Hum Pathol 2004 Aug;35(8):949-60. doi: 10.1016/j.humpath.2004.03.006. PMID: 15297962
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620
Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors: atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas.
Riopel MA, Ronnett BM, Kurman RJ
Am J Surg Pathol 1999 Jun;23(6):617-35. doi: 10.1097/00000478-199906000-00001. PMID: 10366144

Recent clinical studies

Etiology

Assessing the landscape of ovarian serous borderline tumors.
Messini I, Doulgeraki T, Chrysanthakis D, Yiannou P, Gavresea T, Papadimitriou C, Panoskaltsis T, Voulgaris Z, Vlachos A, Pavlakis K
Int J Gynecol Cancer 2019 Mar;29(3):572-578. Epub 2019 Jan 18 doi: 10.1136/ijgc-2018-000086. PMID: 30659030
Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion.
Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S
Int J Gynecol Pathol 2011 May;30(3):218-30. doi: 10.1097/PGP.0b013e3181fcf01a. PMID: 21464732
The relationship between papillary infarction and microinvasion in ovarian atypical proliferative ("borderline") serous and seromucinous tumors.
Kraus JA, Seidman JD
Int J Gynecol Pathol 2010 Jul;29(4):303-9. doi: 10.1097/PGP.0b013e3181cc824f. PMID: 20567140
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848

Diagnosis

Assessing the landscape of ovarian serous borderline tumors.
Messini I, Doulgeraki T, Chrysanthakis D, Yiannou P, Gavresea T, Papadimitriou C, Panoskaltsis T, Voulgaris Z, Vlachos A, Pavlakis K
Int J Gynecol Cancer 2019 Mar;29(3):572-578. Epub 2019 Jan 18 doi: 10.1136/ijgc-2018-000086. PMID: 30659030
Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion.
Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S
Int J Gynecol Pathol 2011 May;30(3):218-30. doi: 10.1097/PGP.0b013e3181fcf01a. PMID: 21464732
Mucinous borderline ovarian tumors: points of general agreement and persistent controversies regarding nomenclature, diagnostic criteria, and behavior.
Ronnett BM, Kajdacsy-Balla A, Gilks CB, Merino MJ, Silva E, Werness BA, Young RH
Hum Pathol 2004 Aug;35(8):949-60. doi: 10.1016/j.humpath.2004.03.006. PMID: 15297962
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848

Therapy

Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.
Seidman JD, Kurman RJ
Hum Pathol 2000 May;31(5):539-57. doi: 10.1053/hp.2000.8048. PMID: 10836293

Prognosis

Assessing the landscape of ovarian serous borderline tumors.
Messini I, Doulgeraki T, Chrysanthakis D, Yiannou P, Gavresea T, Papadimitriou C, Panoskaltsis T, Voulgaris Z, Vlachos A, Pavlakis K
Int J Gynecol Cancer 2019 Mar;29(3):572-578. Epub 2019 Jan 18 doi: 10.1136/ijgc-2018-000086. PMID: 30659030
Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion.
Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S
Int J Gynecol Pathol 2011 May;30(3):218-30. doi: 10.1097/PGP.0b013e3181fcf01a. PMID: 21464732
Serous borderline (low malignant potential, atypical proliferative) ovarian tumors: workshop perspectives.
Bell DA, Longacre TA, Prat J, Kohn EC, Soslow RA, Ellenson LH, Malpica A, Stoler MH, Kurman RJ
Hum Pathol 2004 Aug;35(8):934-48. doi: 10.1016/j.humpath.2004.03.005. PMID: 15297961
Diagnostic criteria and behavior of ovarian seromucinous (endocervical-type mucinous and mixed cell-type) tumors: atypical proliferative (borderline) tumors, intraepithelial, microinvasive, and invasive carcinomas.
Shappell HW, Riopel MA, Smith Sehdev AE, Ronnett BM, Kurman RJ
Am J Surg Pathol 2002 Dec;26(12):1529-41. doi: 10.1097/00000478-200212000-00001. PMID: 12459620
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848

Clinical prediction guides

Long-term Behavior of Serous Borderline Tumors Subdivided Into Atypical Proliferative Tumors and Noninvasive Low-grade Carcinomas: A Population-based Clinicopathologic Study of 942 Cases.
Vang R, Hannibal CG, Junge J, Frederiksen K, Kjaer SK, Kurman RJ
Am J Surg Pathol 2017 Jun;41(6):725-737. doi: 10.1097/PAS.0000000000000824. PMID: 28248817Free PMC Article
Mucinous tumor of low malignant potential ("borderline" or "atypical proliferative" tumor) of the ovary: a study of 171 cases with the assessment of intraepithelial carcinoma and microinvasion.
Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S
Int J Gynecol Pathol 2011 May;30(3):218-30. doi: 10.1097/PGP.0b013e3181fcf01a. PMID: 21464732
The relationship between papillary infarction and microinvasion in ovarian atypical proliferative ("borderline") serous and seromucinous tumors.
Kraus JA, Seidman JD
Int J Gynecol Pathol 2010 Jul;29(4):303-9. doi: 10.1097/PGP.0b013e3181cc824f. PMID: 20567140
A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary.
Bell KA, Kurman RJ
Am J Surg Pathol 2000 Nov;24(11):1465-79. doi: 10.1097/00000478-200011000-00002. PMID: 11075848
Ovarian serous borderline tumors: a critical review of the literature with emphasis on prognostic indicators.
Seidman JD, Kurman RJ
Hum Pathol 2000 May;31(5):539-57. doi: 10.1053/hp.2000.8048. PMID: 10836293

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