Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Ovarian benign neoplasm

MedGen UID:: 14058
•Concept ID:: C0004997
•: Neoplastic Process

Synonyms:	Benign neoplasm of ovary; Benign Neoplasm of Ovary; benign neoplasm of ovary; Benign Neoplasm of the Ovary; benign neoplasm of the ovary; Benign Ovarian Neoplasm; benign ovarian neoplasm; Benign ovarian tumor; Benign Ovarian Tumor; benign ovarian tumor; benign ovarian tumour; Benign Tumor of Ovary; benign tumor of ovary; Benign Tumor of the Ovary; benign tumor of the ovary; benign tumour of ovary; benign tumour of the ovary; ovarian benign neoplasm; ovary benign neoplasm
SNOMED CT:	Benign ovarian tumor (92260003); Benign neoplasm of ovary (92260003)

Monarch Initiative:	MONDO:0000646

Definition

A neoplasm that arises from the ovary and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include serous cystadenoma, mucinous cystadenoma, clear cell adenofibroma, benign Brenner tumor, thecoma, and fibroma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVOvarian benign neoplasm

Neoplasm
- Neoplasm by Special Category
  - Benign neoplasm
    - Benign Genitourinary System Neoplasm
      - Benign reproductive system neoplasm
        Benign female reproductive system neoplasm
        Ovarian benign neoplasm
        Benign Ovarian Epithelial Tumor
        Benign Ovarian Brenner Tumor
        Benign Ovarian Clear Cell Tumor
        Ovarian clear cell adenofibroma
        Benign Ovarian Endometrioid Tumor
        Ovarian endometrioid adenofibroma
        Ovarian endometrioid cystadenoma
        Benign ovarian mucinous tumor
        Mucinous ovarian cystadenoma
        Ovarian mucinous adenofibroma
        Benign Ovarian Seromucinous Tumor
        Ovarian Seromucinous Adenofibroma
        Ovarian Seromucinous Cystadenoma
        Benign Ovarian Serous Tumor
        Ovarian serous adenofibroma
        Ovarian serous cystadenoma
        Ovarian surface papilloma
        Ovarian cystadenoma
        Benign Ovarian Germ Cell Tumor
        Mature ovarian teratoma
        Childhood mature teratoma of the ovary
        Ovarian dermoid cyst
        Ovarian fetiform teratoma
        Ovarian solid teratoma
        Benign ovarian sex cord-stromal tumor
        Benign Ovarian Thecoma
        Benign Ovarian Luteinized Thecoma
        Typical Ovarian Thecoma
        Fibroma of ovary
        Ovarian Cellular Fibroma
        Ovarian microcystic stromal tumor
        Ovarian Sclerosing Stromal Tumor
        Ovarian Stromal-Leydig Cell Tumor
        Ovarian Adenomatoid Tumor
        Ovarian Leiomyoma
        Ovarian Myxoma

Professional guidelines

PubMed

The prevalence of plasma heparin neutralizing activity and the effect of treatment on it in women with a gynecologic malignancy.

Wentworth P, Weiner C, Abas T, Turner D
Am J Obstet Gynecol 1988 Jul;159(1):194-9. doi: 10.1016/0002-9378(88)90520-0. PMID: 3260749

See all (1)

Recent clinical studies

Etiology

Ovarian-sparing surgery for ovarian tumors in children: A systematic review and meta-analysis.

Pio L, Abu-Zaid A, Zaghloul T, Halepota HF, Davidoff AM, Losty PD, Abdelhafeez HH
Eur J Surg Oncol 2023 Oct;49(10):106923. Epub 2023 May 18 doi: 10.1016/j.ejso.2023.04.022. PMID: 37211469

Guideline No. 403: Initial Investigation and Management of Adnexal Masses.

Salvador S, Scott S, Glanc P, Eiriksson L, Jang JH, Sebastianelli A, Dean E
J Obstet Gynaecol Can 2020 Aug;42(8):1021-1029.e3. doi: 10.1016/j.jogc.2019.08.044. PMID: 32736853

Adnexal Masses in Adolescents.

Northridge JL
Pediatr Ann 2020 Apr 1;49(4):e183-e187. doi: 10.3928/19382359-20200227-01. PMID: 32275763

The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory.

Kurman RJ, Shih IeM
Am J Surg Pathol 2010 Mar;34(3):433-43. doi: 10.1097/PAS.0b013e3181cf3d79. PMID: 20154587 Free PMC Article

Teratomas in childhood.

Bale PM, Painter DM, Cohen D
Pathology 1975 Jul;7(3):209-18. doi: 10.3109/00313027509094411. PMID: 1196679

See all (39127)

Diagnosis

Malignant transformation of mature cystic teratoma of the ovary.

Atwi D, Kamal M, Quinton M, Hassell LA
J Obstet Gynaecol Res 2022 Dec;48(12):3068-3076. Epub 2022 Sep 2 doi: 10.1111/jog.15409. PMID: 36053141

Brenner tumors.

Costeira FS, Félix A, Cunha TM
Br J Radiol 2022 Feb 1;95(1130):20210687. Epub 2021 Dec 20 doi: 10.1259/bjr.20210687. PMID: 34928171 Free PMC Article

Adnexal Masses in Adolescents.

Northridge JL
Pediatr Ann 2020 Apr 1;49(4):e183-e187. doi: 10.3928/19382359-20200227-01. PMID: 32275763

Ovarian neoplasms of childhood.

Lala SV, Strubel N
Pediatr Radiol 2019 Oct;49(11):1463-1475. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04456-8. PMID: 31620847

Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria.

Hauptmann S, Friedrich K, Redline R, Avril S
Virchows Arch 2017 Feb;470(2):125-142. Epub 2016 Dec 27 doi: 10.1007/s00428-016-2040-8. PMID: 28025670 Free PMC Article

See all (41007)

Therapy

Immuno-Oncology for Gynecologic Malignancies.

How JA, Patel A, Jazaeri AA
Adv Exp Med Biol 2021;1342:193-232. doi: 10.1007/978-3-030-79308-1_6. PMID: 34972966

Primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for FIGO stage III epithelial ovarian cancer: OVHIPEC-2, a phase III randomized clinical trial.

Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A, Colombo PE, Sonke G, Driel WJV; OVHIPEC-2 Steering Committee and the Dutch OVHIPEC group
Int J Gynecol Cancer 2020 Jun;30(6):888-892. Epub 2020 Mar 23 doi: 10.1136/ijgc-2020-001231. PMID: 32205449 Free PMC Article

Ovarian Cancer: Clinical Trial Breakthroughs and Impact on Management.

Previs RA, Secord AA
Obstet Gynecol Clin North Am 2019 Mar;46(1):67-88. doi: 10.1016/j.ogc.2018.09.005. PMID: 30683267

Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.

Oktay K, Harvey BE, Partridge AH, Quinn GP, Reinecke J, Taylor HS, Wallace WH, Wang ET, Loren AW
J Clin Oncol 2018 Jul 1;36(19):1994-2001. Epub 2018 Apr 5 doi: 10.1200/JCO.2018.78.1914. PMID: 29620997

Survival analysis part I: basic concepts and first analyses.

Clark TG, Bradburn MJ, Love SB, Altman DG
Br J Cancer 2003 Jul 21;89(2):232-8. doi: 10.1038/sj.bjc.6601118. PMID: 12865907 Free PMC Article

See all (31057)

Prognosis

Ovarian cancer today and tomorrow: A global assessment by world region and Human Development Index using GLOBOCAN 2020.

Cabasag CJ, Fagan PJ, Ferlay J, Vignat J, Laversanne M, Liu L, van der Aa MA, Bray F, Soerjomataram I
Int J Cancer 2022 Nov 1;151(9):1535-1541. Epub 2022 Mar 30 doi: 10.1002/ijc.34002. PMID: 35322413

Prediagnosis and postdiagnosis leisure time physical activity and survival following diagnosis with ovarian cancer.

Wang T, Townsend MK, Eliassen AH, Terry KL, Song M, Irwin ML, Tworoger SS
Int J Cancer 2021 Sep 1;149(5):1067-1075. Epub 2021 May 21 doi: 10.1002/ijc.33676. PMID: 33963766 Free PMC Article

Association of Radiotherapy for Rectal Cancer and Second Gynecological Malignant Neoplasms.

Guan X, Wei R, Yang R, Lu Z, Liu E, Zhao Z, Chen H, Yang M, Liu Z, Jiang Z, Wang X
JAMA Netw Open 2021 Jan 4;4(1):e2031661. doi: 10.1001/jamanetworkopen.2020.31661. PMID: 33416884 Free PMC Article

Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.

Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082

Do patients have worse outcomes in heart failure than in cancer? A primary care-based cohort study with 10-year follow-up in Scotland.

Mamas MA, Sperrin M, Watson MC, Coutts A, Wilde K, Burton C, Kadam UT, Kwok CS, Clark AB, Murchie P, Buchan I, Hannaford PC, Myint PK
Eur J Heart Fail 2017 Sep;19(9):1095-1104. Epub 2017 May 3 doi: 10.1002/ejhf.822. PMID: 28470962

See all (30673)

Clinical prediction guides

Reducing Unnecessary Oophorectomies for Benign Ovarian Neoplasms in Pediatric Patients.

Minneci PC, Bergus KC, Lutz C, Aldrink J, Bence C, Breech L, Dillon PA, Downard C, Ehrlich PF, Fallat M, Fraser JD, Grabowski J, Helmrath M, Hertweck P, Hewitt G, Hirschl RB, Kabre R, Lal DR, Landman M, Leys C, Mak G, Markel T, Pressey J, Raiji M, Rymeski B, Saito J, Sato TT, St Peter SD, Cooper J, Deans K; Midwest Pediatric Surgery Consortium
JAMA 2023 Oct 3;330(13):1247-1254. doi: 10.1001/jama.2023.17183. PMID: 37787794 Free PMC Article

Chemotherapy Response Score: Development and Validation of a System to Quantify Histopathologic Response to Neoadjuvant Chemotherapy in Tubo-Ovarian High-Grade Serous Carcinoma.

Böhm S, Faruqi A, Said I, Lockley M, Brockbank E, Jeyarajah A, Fitzpatrick A, Ennis D, Dowe T, Santos JL, Cook LS, Tinker AV, Le ND, Gilks CB, Singh N
J Clin Oncol 2015 Aug 1;33(22):2457-63. Epub 2015 Jun 29 doi: 10.1200/JCO.2014.60.5212. PMID: 26124480

Ovarian incidentaloma.

Solnik MJ, Alexander C
Best Pract Res Clin Endocrinol Metab 2012 Feb;26(1):105-16. doi: 10.1016/j.beem.2011.07.002. PMID: 22305456

A laparoscopy-based score to predict surgical outcome in patients with advanced ovarian carcinoma: a pilot study.

Fagotti A, Ferrandina G, Fanfani F, Ercoli A, Lorusso D, Rossi M, Scambia G
Ann Surg Oncol 2006 Aug;13(8):1156-61. Epub 2006 Jun 21 doi: 10.1245/ASO.2006.08.021. PMID: 16791447

Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.

DeLong ER, DeLong DM, Clarke-Pearson DL
Biometrics 1988 Sep;44(3):837-45. PMID: 3203132

See all (28348)

Recent systematic reviews

Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer: a systematic review and meta-analysis of randomized trials.

Filis P, Mauri D, Markozannes G, Tolia M, Filis N, Tsilidis K
ESMO Open 2022 Oct;7(5):100586. Epub 2022 Sep 16 doi: 10.1016/j.esmoop.2022.100586. PMID: 36116421 Free PMC Article

BRCA Genes and Related Cancers: A Meta-Analysis from Epidemiological Cohort Studies.

Lee YC, Lee YL, Li CY
Medicina (Kaunas) 2021 Aug 30;57(9) doi: 10.3390/medicina57090905. PMID: 34577828 Free PMC Article

Use of oral contraceptives in BRCA mutation carriers and risk for ovarian and breast cancer: a systematic review.

Huber D, Seitz S, Kast K, Emons G, Ortmann O
Arch Gynecol Obstet 2020 Apr;301(4):875-884. Epub 2020 Mar 5 doi: 10.1007/s00404-020-05458-w. PMID: 32140806 Free PMC Article

Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update.

Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis.

Barry JA, Azizia MM, Hardiman PJ
Hum Reprod Update 2014 Sep-Oct;20(5):748-58. Epub 2014 Mar 30 doi: 10.1093/humupd/dmu012. PMID: 24688118 Free PMC Article

See all (1395)

MedGen

National Center for Biotechnology Information

Send to:

Ovarian benign neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

Related information

Recent activity