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| Status |
Public on Jul 01, 2016 |
| Title |
Mapping Variation in Cellular and Transcriptional Response to 1,25-dihydroxyvitamin D3 in Peripheral Blood Mononuclear Cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
This study characterizes the genetic basis of variation in the immunomodulatory effects of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D). This was done by mapping quantitative traits of 1,25D response both at the cellular and transcriptional level in peripheral blood mononuclear cells (PBMCs).
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| Overall design |
Total RNA extraced from peripheral blood mononuclear cells from 85 healthy individuals of African-African ancestry treated with 1,25D or the vehicle control, ethanol, for 6 hours.
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| Contributor(s) |
Kariuki SN, Maranville JC, Baxter SS, Jeong C, Nakagome S, Hrusch CL, Witonsky DB, Sperling AI, Di Rienzo A |
| Citation(s) |
27454520 |
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| Submission date |
May 30, 2016 |
| Last update date |
Aug 13, 2018 |
| Contact name |
Silvia Kariuki |
| Organization name |
University of Chicago
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| Department |
Human Genetics
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| Lab |
Di Rienzo Lab
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| Street address |
920 E. 58th St.
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| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60637 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (170)
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| Relations |
| BioProject |
PRJNA323715 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE82023_RAW.tar |
26.2 Mb |
(http)(custom) |
TAR |
| GSE82023_non_normalized.txt.gz |
28.3 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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