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| Status |
Public on Sep 03, 2014 |
| Title |
Expression data of neural progenitor cells differentiation from human embryonic stem cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Mocetinostat (MGCD) which is a kind of histone deacetylase inhibitors (HDACi) promotes human embryonic stem cells (hESCs) differentiation towards neural progenitor cells (NPCs). Application of HDAC inhibitors (HDACi) increased the expression of neuroectodermal markers once neural differentiation was initiated, thereby leading to more NPC generation.
We used microarrays to detail the global gene expression during NPC differentiaton upon MGCD treatment and identified the transcript changes effected by MGCD during this process.
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| Overall design |
Undifferentiated H9 hESCs (D0), as well as H9 cells with or without MGCD treatment on day 3 (D3C and D3M) and on day 7(D7C and D7M) of NPC generation were collected for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Le W, Yang J, Tang Y |
| Citation(s) |
25406762 |
| |
| Submission date |
Sep 03, 2014 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Weidong Le |
| E-mail(s) |
wdle@sibs.ac.cn
|
| Organization name |
Institute of Health Sciences
|
| Street address |
#197 Ruijin No.2 Road
|
| City |
Shanghai |
| ZIP/Postal code |
200025 |
| Country |
China |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA260157 |
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