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| Status |
Public on Jul 22, 2023 |
| Title |
Inhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome |
| Organism |
Homo sapiens |
| Experiment type |
Methylation profiling by high throughput sequencing
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| Summary |
Profiling of DNA methylation
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| Overall design |
Comparative DNA methylation profiling analysis of Oxford nanopore PromethION data for 5mM or 25mM glucose treated Hep3B cells and its mutants (myc-DNMT1-WT, myc-DNMT1-S878A).
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| Contributor(s) |
Shin H, Leung A, Costello KR, Senapati P, Kato H, Moore RE, Lee M, Lin D, Tang X, Pirrotte P, Chen ZB, Schones DE |
| Citation(s) |
37470704 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 CA220693 |
Epigenetic damage in women living in LA food-desert zip codes |
Beckman Research Institute of the City of Hope |
Dustin Edward Schones |
| R01 DK112041 |
Epigenetic dysregulation of transposons in obesity |
Beckman Research Institute of the City of Hope |
Dustin Edward Schones |
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| Submission date |
Apr 25, 2022 |
| Last update date |
Jul 24, 2023 |
| Contact name |
Heon Shin |
| E-mail(s) |
hshin@coh.org
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| Organization name |
City of Hope
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| Street address |
1500 E Duarte Rd, Gonda, 2132B
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| City |
Duarte |
| ZIP/Postal code |
91010 |
| Country |
USA |
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| Platforms (1) |
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| Samples (8)
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| GSM6065194 |
Hep3B, DNMT1-WT, 5mM Glucose, Replicate 1 |
| GSM6065195 |
Hep3B, DNMT1-WT, 5mM Glucose, Replicate 2 |
| GSM6065196 |
Hep3B, DNMT1-WT, 25mM Glucose, Thiamet-G, Replicate 1 |
| GSM6065197 |
Hep3B, DNMT1-WT, 25mM Glucose, Thiamet-G, Replicate 2 |
| GSM6065198 |
Hep3B, DNMT1-S878A, 5mM Glucose, Replicate 1 |
| GSM6065199 |
Hep3B, DNMT1-S878A, 5mM Glucose, Replicate 2 |
| GSM6065200 |
Hep3B, DNMT1-S878A, 25mM Glucose, Thiamet-G, Replicate 1 |
| GSM6065201 |
Hep3B, DNMT1-S878A, 25mM Glucose, Thiamet-G, Replicate 2 |
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| Relations |
| BioProject |
PRJNA831845 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE201470_RAW.tar |
1.7 Gb |
(http)(custom) |
TAR (of BW) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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