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Series GSE10824 Query DataSets for GSE10824
Status Public on Dec 05, 2008
Title Gene expression levels in African Americans vary with genetic ancestry at most expressed genes
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Variation in gene expression is a fundamental aspect of human phenotypic variation. Several studies have analyzed gene expression levels in populations of different continental ancestry, and concluded that there is variation across populations at a fraction of expressed genes.
Here we analyze gene expression levels in African American cell lines, which differ from previously analyzed cell lines in that samples from this population have variable proportions of continental ancestry. We show that for most genes examined, gene expression varies with genetic ancestry.
Keywords: Human Gene Expression Study
 
Overall design Lymphoblastoid cell lines (LCL) for 60 HapMap CEU, 60 HapMap YRI, and 82 AFA from the Human Variation Panel were obtained from Coriell Cell Repositories. LCLs were grown in culture, total RNA was extracted and hybridized to Affymetrix HG-FOCUS arrays.
 
Contributor(s) Price AL, Patterson N, Hancks DC, Reich D, Cheung VG, Spielman RS
Citation(s) 19057673
Submission date Mar 14, 2008
Last update date Jul 08, 2016
Contact name Dustin Hancks
E-mail(s) hancks@mail.med.upenn.edu
Phone 215-898-2080
Organization name University of Pennsylvania
Department Genetics
Lab Kazazian
Street address 415 curie blvd rm 515 crb
City philadelphia
State/province PA
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL201 [HG-Focus] Affymetrix Human HG-Focus Target Array
Samples (244)
GSM273271 GM06985
GSM273272 GM06985, Technical replicate
GSM273273 GM06993
Relations
BioProject PRJNA107429

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE10824_RAW.tar 332.2 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
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