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    Taf13 TATA-box binding protein associated factor 13 [ Mus musculus (house mouse) ]

    Gene ID: 99730, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Taf13provided by MGI
    Official Full Name
    TATA-box binding protein associated factor 13provided by MGI
    Primary source
    MGI:MGI:1913500
    See related
    Ensembl:ENSMUSG00000048100 AllianceGenome:MGI:1913500
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TAFII18; 1810004N01Rik; 2010309N11Rik
    Summary
    Enables DNA binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Is expressed in several structures, including cranial ganglion; limb mesenchyme; sensory organ; submandibular gland primordium; and tail dorsal root ganglion. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 60. Orthologous to human TAF13 (TATA-box binding protein associated factor 13). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 19.4), bladder adult (RPKM 12.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Taf13 in Genome Data Viewer
    Location:
    3 F3; 3 47.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108479015..108489384)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108571699..108582068)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2679 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:108365309-108365496 Neighboring gene STARR-positive B cell enhancer ABC_E3459 Neighboring gene transmembrane protein 167B Neighboring gene small Cajal body-specific RNA 2 Neighboring gene STARR-positive B cell enhancer ABC_E1629 Neighboring gene STARR-positive B cell enhancer ABC_E6105 Neighboring gene WD repeat domain 47 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene chloride channel CLIC-like 1 Neighboring gene G-protein signalling modulator 2 (AGS3-like, C. elegans)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TATA-binding associated factors have distinct roles during early mammalian development. He XD, et al. Dev Biol, 2024 Jul. PMID 38593904,
    2. TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation. Alpern D, et al. Elife, 2014 Sep 10. PMID 25209997, Free PMC Article
    3. Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Langer D, et al. Nat Commun, 2016 Mar 30. PMID 27026076, Free PMC Article
    4. Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death. El-Saafin F, et al. Cell Death Differ, 2022 May. PMID 35361962, Free PMC Article
    5. The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Bardot P, et al. Development, 2017 Oct 15. PMID 28893950, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables TBP-class protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 13
    Names
    TAF(II)18
    TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor
    TAF13 RNA polymerase II, TATA box-binding protein-associated factor
    TAFII-18
    TBP-associated factor, RNA polymerase II, K, 18kD
    transcription initiation factor TFIID 18 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025444.2 → NP_079720.1  transcription initiation factor TFIID subunit 13

      See identical proteins and their annotated locations for NP_079720.1

      Status: PROVISIONAL

      Source sequence(s)
      AK007339
      Consensus CDS
      CCDS17764.1
      UniProtKB/Swiss-Prot
      P61216, Q3TVE8
      Related
      ENSMUSP00000121346.2, ENSMUST00000143054.2
      Conserved Domains (1) summary
      cd07978
      Location:29 → 118
      TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      108479015..108489384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61216.1 GenPept UniProtKB/Swiss-Prot:P61216

    Gene LinkOut

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