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    Zfp451 zinc finger protein 451 [ Mus musculus (house mouse) ]

    Gene ID: 98403, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp451provided by MGI
    Official Full Name
    zinc finger protein 451provided by MGI
    Primary source
    MGI:MGI:2137896
    See related
    Ensembl:ENSMUSG00000042197 AllianceGenome:MGI:2137896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf451; COASTER; mKIAA1702; Kiaa0576-hp; 4930515K21Rik; 4933435G09Rik
    Summary
    Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; SUMO ligase activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Predicted to be located in PML body. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; gonad; and metanephros. Orthologous to human ZNF451 (zinc finger protein 451). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 22.2), CNS E11.5 (RPKM 5.4) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp451 in Genome Data Viewer
    Location:
    1 B; 1 12.81 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33800622..33854683, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33761541..33815602, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RAB23, member RAS oncogene family Neighboring gene BCL2-associated athanogene 2 Neighboring gene STARR-seq mESC enhancer starr_00543 Neighboring gene predicted gene 15455 Neighboring gene BEN domain containing 6 Neighboring gene predicted gene, 38471

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis. Peng H, et al. Respir Res, 2024 Apr 10. PMID 38600524, Free PMC Article
    2. ZFP451-mediated SUMOylation of SATB2 drives embryonic stem cell differentiation. Antonio Urrutia G, et al. Genes Dev, 2021 Aug 1. PMID 34244292, Free PMC Article
    3. ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression. Zhang Y, et al. Cell Rep, 2023 Jun 27. PMID 37342906
    4. The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability. Koidl S, et al. Int J Biochem Cell Biol, 2016 Oct. PMID 27343429
    5. ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. Karvonen U, et al. J Mol Biol, 2008 Oct 10. PMID 18656483

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis.
      Title: Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis.
    2. a regulatory role of ZNF451-1 in fine-tuning physiological PML levels
      Title: The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription regulator inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription initiation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein sumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase ZNF451
    Names
    E3 SUMO-protein transferase ZNF451

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290699.1 → NP_001277628.1  E3 SUMO-protein ligase ZNF451 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC163668, AI596398, AK015797, AK030088
      UniProtKB/TrEMBL
      Q6P6L8
      Conserved Domains (1) summary
      cd18721
      Location:722 → 838
      PIN_ZNF451-like; LabA-like PIN domain of human zinc finger protein 451 and related proteins

    2. NM_001290700.1 → NP_001277629.1  E3 SUMO-protein ligase ZNF451 isoform 3

      See identical proteins and their annotated locations for NP_001277629.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a distinct 3' structure and 3' terminus, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC163668, AK015797
      Consensus CDS
      CCDS69873.1
      UniProtKB/TrEMBL
      Q80TA4, Q8VCL4
      Related
      ENSMUSP00000044372.6, ENSMUST00000044455.8
      Conserved Domains (1) summary
      pfam11560
      Location:357 → 492
      LAP2alpha; Lamina-associated polypeptide 2 alpha

    3. NM_001359274.1 → NP_001346203.1  E3 SUMO-protein ligase ZNF451 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163668
      UniProtKB/TrEMBL
      Q6P6L8

    4. NM_001359275.1 → NP_001346204.1  E3 SUMO-protein ligase ZNF451 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC163668
      UniProtKB/TrEMBL
      Q6P6L8

    5. NM_133817.3 → NP_598578.1  E3 SUMO-protein ligase ZNF451 isoform 1

      See identical proteins and their annotated locations for NP_598578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC163668, AI596398, AK015797, AK030088
      Consensus CDS
      CCDS14865.1
      UniProtKB/Swiss-Prot
      Q8C0P7
      UniProtKB/TrEMBL
      Q6P6L8
      Related
      ENSMUSP00000019861.7, ENSMUST00000019861.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      33800622..33854683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154651.1 → XP_036010544.1  E3 SUMO-protein ligase ZNF451 isoform X1

      UniProtKB/TrEMBL
      Q6P6L8
      Conserved Domains (1) summary
      pfam18479
      Location:741 → 858
      PIN_11; PIN like domain

    2. XM_036154666.1 → XP_036010559.1  E3 SUMO-protein ligase ZNF451 isoform X2

      UniProtKB/TrEMBL
      Q6P6L8
      Conserved Domains (1) summary
      pfam18479
      Location:553 → 670
      PIN_11; PIN like domain

    3. XM_030243891.2 → XP_030099751.1  E3 SUMO-protein ligase ZNF451 isoform X1

      UniProtKB/TrEMBL
      Q6P6L8
      Conserved Domains (1) summary
      pfam18479
      Location:741 → 858
      PIN_11; PIN like domain

    RNA

    1. XR_865290.4 RNA Sequence

    2. XR_865291.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C0P7.1 GenPept UniProtKB/Swiss-Prot:Q8C0P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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