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    SMAD5-AS1 SMAD5 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 9597, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SMAD5-AS1provided by HGNC
    Official Full Name
    SMAD5 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:30586
    See related
    Ensembl:ENSG00000164621 MIM:620035; AllianceGenome:HGNC:30586
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DAMS; SMAD5AS; SMAD5OS
    Summary
    Enables miRNA inhibitor activity via base-pairing. Involved in lncRNA-mediated post-transcriptional gene silencing and positive regulation of BMP signaling pathway. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in skin (RPKM 1.2), liver (RPKM 0.3) and 16 other tissues See more
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    Genomic context

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    See SMAD5-AS1 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (136129513..136134890, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136652045..136657420, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135465202..135470579, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23177 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:135388921-135390120 Neighboring gene transforming growth factor beta induced Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16378 Neighboring gene vault RNA 2-1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23178 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:135488895-135490094 Neighboring gene SMAD family member 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:135527733-135528647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135528804-135529321 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:135537973-135538930 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:135538931-135539888 Neighboring gene small integral membrane protein 32 Neighboring gene TRPC7 antisense RNA 1 Neighboring gene transient receptor potential cation channel subfamily C member 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Silencing of Long Non-coding RNA SMAD5-AS1 Reverses Epithelial Mesenchymal Transition in Nasopharyngeal Carcinoma via microRNA-195-Dependent Inhibition of SMAD5. Li S, et al. Front Oncol, 2019. PMID 31921616, Free PMC Article
    2. Long noncoding RNA SMAD5-AS1 acts as a microRNA-106a-5p sponge to promote epithelial mesenchymal transition in nasopharyngeal carcinoma. Zheng YJ, et al. FASEB J, 2019 Nov. PMID 31557058, Free PMC Article
    3. Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC. Zhao CC, et al. Cell Death Dis, 2019 Mar 15. PMID 30874550, Free PMC Article
    4. An antisense transcript to SMAD5 expressed in fetal and tumor tissues. Zavadil J, et al. Biochem Biophys Res Commun, 1999 Feb 24. PMID 10049768

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMAD5-AS1 silencing suppressed epithelial-mesenchymal transition, cell proliferation, migration, and invasion in nasopharyngeal carcinoma (NPC) by elevating miR-106a-5p to down-regulate SMAD5, which provided a novel therapeutic target for NPC treatment
      Title: Long noncoding RNA SMAD5-AS1 acts as a microRNA-106a-5p sponge to promote epithelial mesenchymal transition in nasopharyngeal carcinoma.
    2. SMAD5-AS1 inhibits diffuse large B cell lymphoma proliferation by sponging miR-135b-5p to up-regulate APC expression and inactivate classic Wnt/beta-catenin pathway.
      Title: Lnc SMAD5-AS1 as ceRNA inhibit proliferation of diffuse large B cell lymphoma via Wnt/β-catenin pathway by sponging miR-135b-5p to elevate expression of APC.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • SMAD family member 5 opposite strand
    • SMAD family member 5, antisense
    • SMAD in the antisense orientation
    • SMAD5 antisense RNA 1 (non-protein coding)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables miRNA inhibitor activity via base-pairing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lncRNA-mediated post-transcriptional gene silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026763.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AF071111
      Related
      ENST00000297163.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      136129513..136134890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      136652045..136657420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_022001.1: Suppressed sequence

      Description
      NM_022001.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y6J3.1 GenPept UniProtKB/Swiss-Prot:Q9Y6J3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials