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    WTAP WT1 associated protein [ Homo sapiens (human) ]

    Gene ID: 9589, updated on 3-Nov-2024

    Summary

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    Official Symbol
    WTAPprovided by HGNC
    Official Full Name
    WT1 associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16846
    See related
    Ensembl:ENSG00000146457 MIM:605442; AllianceGenome:HGNC:16846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mum2
    Summary
    The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]
    Expression
    Ubiquitous expression in bone marrow (RPKM 44.8), lymph node (RPKM 20.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WTAP in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (159726693..159756319)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (160967457..161001943)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (160148149..160177351)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene superoxide dismutase 2 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 pseudogene 1 Neighboring gene RNA, U4atac small nuclear 18, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:160147749-160148346 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:160148347-160148944 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:160154720-160154980 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25391 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:160184458-160184958 Neighboring gene SOD2 overlapping transcript 1 Neighboring gene acetyl-CoA acetyltransferase 2 Neighboring gene small nucleolar RNA, H/ACA box 20 Neighboring gene t-complex 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of WTAP-related genes by weighted gene co-expression network analysis in ovarian cancer. Wang J, et al. J Ovarian Res, 2020 Sep 30. PMID 32998774, Free PMC Article
    2. The contribution of WTAP gene variants to Wilms tumor susceptibility. Ma L, et al. Gene, 2020 Sep 5. PMID 32504654
    3. WTAP promotes oesophageal squamous cell carcinoma development by decreasing CPSF4 expression in an m(6)A-dependent manner. Luo Q, et al. Med Oncol, 2022 Sep 29. PMID 36175708
    4. High expression of WTAP leads to poor prognosis of gastric cancer by influencing tumour-associated T lymphocyte infiltration. Li H, et al. J Cell Mol Med, 2020 Apr. PMID 32176425, Free PMC Article
    5. Role of WTAP in Cancer: From Mechanisms to the Therapeutic Potential. Fan Y, et al. Biomolecules, 2022 Sep 2. PMID 36139062, Free PMC Article

    See all (167) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WTAP-dependent N6-methyladenosine methylation of lncRNA TEX41 promotes renal cell carcinoma progression.
      Title: WTAP-dependent N6-methyladenosine methylation of lncRNA TEX41 promotes renal cell carcinoma progression.
    2. WTAP mediated m6A-modified circ_0056856 contributes to the proliferation, migration, and invasion of IL-22-stimulated human keratinocyte by miR-197-3p/CDK1 axis.
      Title: WTAP mediated m6A-modified circ_0056856 contributes to the proliferation, migration, and invasion of IL-22-stimulated human keratinocyte by miR-197-3p/CDK1 axis.
    3. WTAP-Involved the m6A Modification of lncRNA FAM83H-AS1 Accelerates the Development of Gastric Cancer.
      Title: WTAP-Involved the m6A Modification of lncRNA FAM83H-AS1 Accelerates the Development of Gastric Cancer.
    4. WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY.
      Title: WTAP-MEDIATED M6A MODIFICATION OF KLF6 AGGRAVATES HYPOXIA/REOXYGENATION-INDUCED HUMAN CARDIOMYOCYTE INJURY.
    5. Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models.
      Title: Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models.
    6. WTAP promotes proliferation of esophageal squamous cell carcinoma via m[6]A-dependent epigenetic promoting of PTP4A1.
      Title: WTAP promotes proliferation of esophageal squamous cell carcinoma via m(6)A-dependent epigenetic promoting of PTP4A1.
    7. WTAP-Mediated N6-Methyladenosine of RNAs Facilitate the Pathophysiology of Atopic Dermatitis.
      Title: WTAP-Mediated N6-Methyladenosine of RNAs Facilitate the Pathophysiology of Atopic Dermatitis.
    8. WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in bladder cancer.
      Title: WTAP enhances the instability of SYTL1 mRNA caused by YTHDF2 in bladder cancer.
    9. WTAP Mediates NUPR1 Regulation of LCN2 Through m[6]A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion.
      Title: WTAP Mediates NUPR1 Regulation of LCN2 Through m(6)A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion.
    10. WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma.
      Title: WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma.
    Submit: New GeneRIF Correction See all GeneRIFs (77)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3925, KIAA0105, DKFZp686F20131

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pre-mRNA-splicing regulator WTAP
    Names
    PNAS-132
    Wilms tumor 1 associated protein
    Wilms' tumour 1-associating protein
    female-lethal(2)D homolog
    hFL(2)D
    putative pre-mRNA splicing regulator female-lethal(2D)
    wilms tumor 1-associating protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270531.2 → NP_001257460.1  pre-mRNA-splicing regulator WTAP isoform 1

      See identical proteins and their annotated locations for NP_001257460.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AF374416, BC069192, BG702882, BX387163
      Consensus CDS
      CCDS5266.1
      UniProtKB/Swiss-Prot
      Q15007, Q5TCL8, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2
      UniProtKB/TrEMBL
      A8K489
      Related
      ENSP00000479438.1, ENST00000621533.5
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 222
      Wtap; WTAP/Mum2p family

    2. NM_001270532.2 → NP_001257461.1  pre-mRNA-splicing regulator WTAP isoform 3

      See identical proteins and their annotated locations for NP_001257461.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 3' end sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Variants 5 and 6 both encode the same isoform (3).
      Source sequence(s)
      AA706250, BE906617, CN284477, D14661
      Consensus CDS
      CCDS75542.1
      UniProtKB/TrEMBL
      A0A087X1R4
      Related
      ENSP00000484404.1, ENST00000614346.4
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    3. NM_001270533.2 → NP_001257462.1  pre-mRNA-splicing regulator WTAP isoform 3

      See identical proteins and their annotated locations for NP_001257462.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate 5' and 3' end sequences compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1. Variants 5 and 6 both encode the same isoform (3).
      Source sequence(s)
      AA706250, BG702882, BQ948913, D14661
      Consensus CDS
      CCDS75542.1
      UniProtKB/TrEMBL
      A0A087X1R4
      Related
      ENSP00000487338.1, ENST00000631126.2
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    4. NM_004906.5 → NP_004897.2  pre-mRNA-splicing regulator WTAP isoform 1

      See identical proteins and their annotated locations for NP_004897.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 both encode the same isoform (1).
      Source sequence(s)
      AF374416, BC069192, BE906617
      Consensus CDS
      CCDS5266.1
      UniProtKB/Swiss-Prot
      Q15007, Q5TCL8, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2
      UniProtKB/TrEMBL
      A8K489
      Related
      ENSP00000351141.4, ENST00000358372.8
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 222
      Wtap; WTAP/Mum2p family

    5. NM_152857.3 → NP_690596.1  pre-mRNA-splicing regulator WTAP isoform 2

      See identical proteins and their annotated locations for NP_690596.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has alternate 5' and 3' end sequences compared to variant 1. Because of the frameshift and immediate translation termination, the resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AA706250, BG702882, D14661
      Consensus CDS
      CCDS5267.1
      UniProtKB/Swiss-Prot
      Q15007
      Related
      ENSP00000336911.4, ENST00000337387.4
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    6. NM_152858.3 → NP_690597.1  pre-mRNA-splicing regulator WTAP isoform 2

      See identical proteins and their annotated locations for NP_690597.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate 3' end sequence compared to variant 1, that causes a frameshift and immediate translation termination. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AA706250, BE906617, D14661, DA561768
      Consensus CDS
      CCDS5267.1
      UniProtKB/Swiss-Prot
      Q15007
      Related
      ENSP00000497840.1, ENST00000650096.1
      Conserved Domains (1) summary
      pfam17098
      Location:68 → 150
      Wtap; WTAP/Mum2p family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      159726693..159756319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011514.3 → XP_016867003.1  pre-mRNA-splicing regulator WTAP isoform X1

      UniProtKB/TrEMBL
      A8K489

    2. XM_017011516.3 → XP_016867005.1  pre-mRNA-splicing regulator WTAP isoform X4

    3. XM_047419578.1 → XP_047275534.1  pre-mRNA-splicing regulator WTAP isoform X2

      UniProtKB/Swiss-Prot
      Q15007, Q5TCL8, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2

    4. XM_017011515.2 → XP_016867004.1  pre-mRNA-splicing regulator WTAP isoform X3

      UniProtKB/TrEMBL
      A8K489

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      160967457..161001943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356858.1 → XP_054212833.1  pre-mRNA-splicing regulator WTAP isoform X1

    2. XM_054356861.1 → XP_054212836.1  pre-mRNA-splicing regulator WTAP isoform X4

    3. XM_054356859.1 → XP_054212834.1  pre-mRNA-splicing regulator WTAP isoform X2

      UniProtKB/Swiss-Prot
      Q15007, Q5TCL8, Q5TCL9, Q96T28, Q9BYJ7, Q9H4E2

    4. XM_054356860.1 → XP_054212835.1  pre-mRNA-splicing regulator WTAP isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15007.2 GenPept UniProtKB/Swiss-Prot:Q15007

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