Ece1 endothelin converting enzyme 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ece1provided by RGD
Official Full Name: endothelin converting enzyme 1provided by RGD
Primary source: RGD:620293
See related: EnsemblRapid:ENSRNOG00000014241 AllianceGenome:RGD:620293
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ece
Summary: Enables identical protein binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; and regulation of signal transduction. Located in early endosome; external side of plasma membrane; and secretory granule. Used to study acute kidney failure; congestive heart failure; hyperhomocysteinemia; hypertension; and pulmonary hypertension. Biomarker of acute kidney failure; congestive heart failure; hypertension; nephrotic syndrome; and renal fibrosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 436.7), Lung (RPKM 390.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (155361031..155462723)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (150077679..150179375)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (156215469..156318652)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that miR-199a-5p might protect the spinal cord against I/R-induced injury by negatively regulating the ECE1 which could aid in developing new therapeutic strategies for I/R-induced spinal cord injury
Title: Upregulation of miR-199a-5p Protects Spinal Cord Against Ischemia/Reperfusion-Induced Injury via Downregulation of ECE1 in Rat.
ECE1 regulated the resensitization of responses to calcitonin gene-related peptide in rat mesenteric artery smooth muscle cells and mesenteric arteries, hence, ECE1 inhibitors may attenuate an important vasodilatory pathway implicated in headaches
Title: Endosomal proteolysis regulates calcitonin gene-related peptide responses in mesenteric arteries.
The protective effect of blocking endothelin converting enzyme and inhibiting neutral endopeptidase offers primary stroke prevention outcome as well as improvement of mortality.
Title: Novel therapy approach in primary stroke prevention: simultaneous inhibition of endothelin converting enzyme and neutral endopeptidase in spontaneously hypertensive, stroke-prone rats improves survival.
The three Abeta-degrading enzymes were damaged to different extents in the brain of diabetic rats, and impairment of ECE-1 and IDE partly contributed to the elevated Abeta(1-40) levels in brain of diabetic rats.
Title: Impaired amyloid β-degrading enzymes in brain of streptozotocin-induced diabetic rats.
comparison of vessel diameter and vessel wall thickness with inducible nitric oxide synthase and endothelin converting enzyme-1 immune reactions revealed that the main effect of smoking on the vessel wall is associated with endothelin converting enzyme-1
Title: Effect of smoking on rat basilar artery: correlation with inducible nitric oxide synthase and endothelin converting enzyme-1.
Endosomal endothelin-converting enzyme-1 is a regulator of beta-arrestin-dependent ERK signaling
Title: Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.
By degrading endocytosed SP, ECE-1 promotes the recycling and re-sensitization of NK(1) receptors in endothelial cells, and thereby induces re-sensitization of the pro-inflammatory effects of SP.
Title: Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation.
Report that CGS 35601 and its orally active prodrug CGS 37808 are triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme.
Title: CGS 35601 and its orally active prodrug CGS 37808 as triple inhibitors of endothelin-converting enzyme-1, neutral endopeptidase 24.11, and angiotensin-converting enzyme.
Amiodarone acutely inhibits vascular activity of endothelin-converting enzymes.
Title: Amiodarone acutely inhibits vascular activity of endothelin-converting enzymes.
endothelin-converting enzyme-1 expression is enhanced in acute hypoxic rat aorta.
Title: Enhanced expression of endothelin-1 and endothelin-converting enzyme-1 in acute hypoxic rat aorta.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

BE107816 (e-PCR)
- UniSTS:247082

D4Mit54 (e-PCR), detects polymorphism
- UniSTS:116525

AU049824 (e-PCR)
- UniSTS:146270

D5Mco18 (e-PCR)
- UniSTS:239352

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis involved in innervation	IEA Inferred from Electronic Annotation more info
involved_in axonogenesis involved in innervation	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bradykinin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in bradykinin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in calcitonin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in calcitonin catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ear development	IEA Inferred from Electronic Annotation more info
involved_in ear development	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic heart tube development	IEA Inferred from Electronic Annotation more info
involved_in embryonic heart tube development	ISO Inferred from Sequence Orthology more info
involved_in endothelin maturation	IEA Inferred from Electronic Annotation more info
involved_in endothelin maturation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in hormone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide hormone processing	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pharyngeal system development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cAMP/PKA signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor recycling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor recycling	ISO Inferred from Sequence Orthology more info
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to muscle stretch	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in semaphorin-plexin signaling pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in substance P catabolic process	IEA Inferred from Electronic Annotation more info
involved_in substance P catabolic process	ISO Inferred from Sequence Orthology more info
involved_in sympathetic neuron axon guidance	IEA Inferred from Electronic Annotation more info
involved_in sympathetic neuron axon guidance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Weibel-Palade body	IEA Inferred from Electronic Annotation more info
located_in Weibel-Palade body	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: endothelin-converting enzyme 1

Names: ECE-1

NP_446048.2

EC 3.4.24.71

XP_006239337.1

EC 3.4.24.71

XP_006239338.1

EC 3.4.24.71

XP_063144586.1

EC 3.4.24.71

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053596.2 → NP_446048.2 endothelin-converting enzyme 1

See identical proteins and their annotated locations for NP_446048.2

Status: PROVISIONAL

Source sequence(s)

BC072504

UniProtKB/TrEMBL

A0A0G2K465, A0A8I6AMF9, A6ITF1, F7EP67, Q6IN10

Related

ENSRNOP00000072923.1, ENSRNOT00000077742.3

Conserved Domains (2) summary

cd08662
Location:103 → 752

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

COG3590
Location:90 → 754

PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

155361031..155462723

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288516.1 → XP_063144586.1 endothelin-converting enzyme 1 isoform X2
XM_006239275.5 → XP_006239337.1 endothelin-converting enzyme 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AL15, A0A8I6AMF9

Related

ENSRNOP00000093768.1, ENSRNOT00000108805.2

Conserved Domains (2) summary

cd08662
Location:118 → 767

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

COG3590
Location:105 → 769

PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
XM_006239276.5 → XP_006239338.1 endothelin-converting enzyme 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AJE5, A0A8J8Y3G8

Related

ENSRNOP00000095338.2, ENSRNOT00000096331.2

Conserved Domains (2) summary

cd08662
Location:84 → 733

M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

COG3590
Location:71 → 735

PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]