LDHAL6B lactate dehydrogenase A like 6B [Homo sapiens (human)] - Gene

Summary

Official Symbol: LDHAL6Bprovided by HGNC
Official Full Name: lactate dehydrogenase A like 6Bprovided by HGNC
Primary source: HGNC:HGNC:21481
See related: Ensembl:ENSG00000171989 AllianceGenome:HGNC:21481
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LDHL; LDH6B; LDHAL6
Summary: Predicted to enable L-lactate dehydrogenase activity. Involved in lactate metabolic process and pyruvate metabolic process. Located in nucleus. Part of cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: mouse all
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Genomic context

Location:: 15q22.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (59206843..59208588)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (57008917..57010662)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (59499042..59500787)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables L-lactate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-lactate dehydrogenase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lactate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lactate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pyruvate metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	TAS Traceable Author Statement more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
part_of oxidoreductase complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: L-lactate dehydrogenase A-like 6B

Names: lactate dehydrogenase A-like 6; testicular tissue protein Li 105

NP_149972.1

EC 1.1.1.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033195.3 → NP_149972.1 L-lactate dehydrogenase A-like 6B

See identical proteins and their annotated locations for NP_149972.1

Status: VALIDATED

Source sequence(s)

AY642121, DB511998

Consensus CDS

CCDS10171.1

UniProtKB/Swiss-Prot

Q6DUY4, Q96LI2, Q9BYZ2

UniProtKB/TrEMBL

A0A140VJM9

Related

ENSP00000302393.4, ENST00000307144.6

Conserved Domains (2) summary

cd05293
Location:68 → 376

LDH_1; A subgroup of L-lactate dehydrogenases

TIGR01771
Location:74 → 374

L-LDH-NAD; L-lactate dehydrogenase