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    OXNAD1 oxidoreductase NAD binding domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 92106, updated on 14-Nov-2024

    Summary

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    Official Symbol
    OXNAD1provided by HGNC
    Official Full Name
    oxidoreductase NAD binding domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:25128
    See related
    Ensembl:ENSG00000154814 MIM:620581; AllianceGenome:HGNC:25128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable oxidoreductase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 2.7), appendix (RPKM 1.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See OXNAD1 in Genome Data Viewer
    Location:
    3p25.1-p24.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (16265212..16352095)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (16266369..16353284)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (16306719..16393602)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 15 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:16285879-16286378 Neighboring gene Sharpr-MPRA regulatory region 8904 Neighboring gene uncharacterized LOC124906218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:16297189-16297690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19540 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14113 Neighboring gene diphthamide biosynthesis 3 Neighboring gene uncharacterized LOC107986065 Neighboring gene THAP domain containing 5 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14114 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:16343021-16343602 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:16343603-16344182 Neighboring gene Sharpr-MPRA regulatory region 2856 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:16377723-16378222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14115 Neighboring gene raftlin, lipid raft linker 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14116 Neighboring gene uncharacterized LOC124906220 Neighboring gene NANOG hESC enhancer GRCh37_chr3:16497386-16497905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19545 Neighboring gene uncharacterized LOC124906219 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:16524187-16525039

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Frequent DPH3 promoter mutations in skin cancers. Denisova E, et al. Oncotarget, 2015 Nov 3. PMID 26416425, Free PMC Article
    2. EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma. Yu T, et al. Oncogene, 2023 Feb. PMID 36517590
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624, Free PMC Article
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC15763

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    oxidoreductase NAD-binding domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330670.3 → NP_001317599.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC090953, BC007285
      Consensus CDS
      CCDS87053.1
      UniProtKB/TrEMBL
      B4DQJ7, C9JLB7, F5H620
      Related
      ENSP00000487136.1, ENST00000627468.2
      Conserved Domains (1) summary
      cd00322
      Location:93 → 327
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    2. NM_001330671.3 → NP_001317600.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, CR739022
      Consensus CDS
      CCDS87053.1
      UniProtKB/TrEMBL
      B4DQJ7, C9JLB7, F5H620
      Related
      ENSP00000389872.2, ENST00000435829.6
      Conserved Domains (1) summary
      cd00322
      Location:93 → 327
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    3. NM_001352977.2 → NP_001339906.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, BQ180851
      Consensus CDS
      CCDS2630.1
      UniProtKB/Swiss-Prot
      Q2HYC7, Q59FA4, Q96HP4
      UniProtKB/TrEMBL
      U3KQU8
      Related
      ENSP00000476239.1, ENST00000606098.1
      Conserved Domains (1) summary
      cd00322
      Location:75 → 309
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    4. NM_001352978.2 → NP_001339907.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, CR739022
      Consensus CDS
      CCDS2630.1
      UniProtKB/Swiss-Prot
      Q2HYC7, Q59FA4, Q96HP4
      UniProtKB/TrEMBL
      U3KQU8
      Related
      ENSP00000475547.1, ENST00000605932.5
      Conserved Domains (1) summary
      cd00322
      Location:75 → 309
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    5. NM_001352980.2 → NP_001339909.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090953, BC007285
      UniProtKB/TrEMBL
      U3KQU8
      Conserved Domains (1) summary
      cd00322
      Location:48 → 282
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    6. NM_001352981.2 → NP_001339910.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, BQ180851
      UniProtKB/TrEMBL
      U3KQU8
      Conserved Domains (1) summary
      cd00322
      Location:48 → 282
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    7. NM_001352982.2 → NP_001339911.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953
      UniProtKB/TrEMBL
      U3KQU8
      Conserved Domains (1) summary
      cd00322
      Location:48 → 282
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    8. NM_001352983.2 → NP_001339912.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, CR739022
      UniProtKB/TrEMBL
      U3KQU8
      Conserved Domains (1) summary
      cd00322
      Location:48 → 282
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    9. NM_138381.5 → NP_612390.1  oxidoreductase NAD-binding domain-containing protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_612390.1

      Status: VALIDATED

      Source sequence(s)
      AC090953, BC007285, BC008322, HY044078
      Consensus CDS
      CCDS2630.1
      UniProtKB/Swiss-Prot
      Q2HYC7, Q59FA4, Q96HP4
      UniProtKB/TrEMBL
      U3KQU8
      Related
      ENSP00000285083.5, ENST00000285083.10
      Conserved Domains (1) summary
      cd00322
      Location:75 → 309
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    RNA

    1. NR_148217.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, BQ180851

    2. NR_148218.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, BQ180851

    3. NR_148219.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, BQ180851

    4. NR_148220.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090948, AC090953, CR739022

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      16265212..16352095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534230.4 → XP_011532532.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011532532.1

      UniProtKB/TrEMBL
      B4DQJ7
      Conserved Domains (1) summary
      cd00322
      Location:148 → 382
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    2. XM_011534235.4 → XP_011532537.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011532537.1

      UniProtKB/TrEMBL
      B4DQJ7
      Conserved Domains (1) summary
      cd00322
      Location:148 → 382
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    3. XM_005265559.5 → XP_005265616.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005265616.1

      UniProtKB/TrEMBL
      B4DQJ7
      Conserved Domains (1) summary
      cd00322
      Location:148 → 382
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...

    RNA

    1. XR_007095766.1 RNA Sequence

    2. XR_007095767.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      16266369..16353284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348411.1 → XP_054204386.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

    2. XM_054348412.1 → XP_054204387.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

    3. XM_054348413.1 → XP_054204388.1  oxidoreductase NAD-binding domain-containing protein 1 isoform X1

    RNA

    1. XR_008486850.1 RNA Sequence

    2. XR_008486851.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96HP4.1 GenPept UniProtKB/Swiss-Prot:Q96HP4

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