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    NAM8 Nam8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856486, updated on 29-Jun-2024

    Summary

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    Gene symbol
    NAM8
    Gene description
    Nam8p
    Primary source
    FungiDB:YHR086W
    Locus tag
    YHR086W
    See related
    SGD:S000001128; AllianceGenome:SGD:S000001128; VEuPathDB:YHR086W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MRE2; MUD15
    Summary
    Enables mRNA binding activity. Involved in mRNA splice site selection and positive regulation of mRNA splicing, via spliceosome. Located in cytoplasm and nucleus. Part of U1 snRNP; U2-type prespliceosome; and commitment complex. Orthologous to human TIA1 (TIA1 cytotoxic granule associated RNA binding protein) and TIAL1 (TIA1 cytotoxic granule associated RNA binding protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NAM8 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (278153..279724)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene homeodomain family transcription factor STE12 Neighboring gene Ipi1p Neighboring gene uncharacterized protein Neighboring gene Rtc3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection. Puig O, et al. Genes Dev, 1999 Mar 1. PMID 10072385, Free PMC Article
    2. The NAM8 gene in Saccharomyces cerevisiae encodes a protein with putative RNA binding motifs and acts as a suppressor of mitochondrial splicing deficiencies when overexpressed. Ekwall K, et al. Mol Gen Genet, 1992 May. PMID 1603056
    3. A novel class of mRNA-containing cytoplasmic granules are produced in response to UV-irradiation. Gaillard H, et al. Mol Biol Cell, 2008 Nov. PMID 18768757, Free PMC Article
    4. Splicing of the meiosis-specific HOP2 transcript utilizes a unique 5' splice site. Leu JY, et al. Mol Cell Biol, 1999 Dec. PMID 10567519, Free PMC Article
    5. Involvement of the MRE2 gene of yeast in formation of meiosis-specific double-strand breaks and crossover recombination through RNA splicing. Nakagawa T, et al. Genes Cells, 1997 Jan. PMID 9112441

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splice site recognition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U1 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of commitment complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nam8p
    NP_011954.1
    • RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      278153..279724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179216.1 → NP_011954.1  TPA: Nam8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL37, Q00539
      UniProtKB/TrEMBL
      A0A8H4FB56, B3LSK3, B5VK18, C8Z9N0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00539.2

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