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    CTF19 Ctf19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856089, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CTF19
    Official Full Name
    Ctf19p
    Primary source
    SGD:S000005939
    Locus tag
    YPL018W
    See related
    AllianceGenome:SGD:S000005939; FungiDB:YPL018W; VEuPathDB:YPL018W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MCM18
    Summary
    Involved in several processes, including establishment of mitotic sister chromatid cohesion; mitotic spindle assembly checkpoint signaling; and protein localization to chromosome, centromeric region. Located in kinetochore and nucleus. Part of COMA complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CTF19 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (517651..518760)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene SUMO protease ULP1 Neighboring gene vacuolar transporter chaperone Neighboring gene Irc15p Neighboring gene Swi1p Neighboring gene histone deacetylase HST2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of Ctf3 and COMA subcomplexes in meiosis: Implication in maintaining Cse4 at the centromere and numeric spindle poles. Agarwal M, et al. Biochim Biophys Acta, 2015 Mar. PMID 25562757
    2. Budding yeast kinetochore proteins, Chl4 and Ctf19, are required to maintain SPB-centromere proximity during G1 and late anaphase. Sau S, et al. PLoS One, 2014. PMID 25003500, Free PMC Article
    3. Functional characterization of kinetochore protein, Ctf19 in meiosis I: an implication of differential impact of Ctf19 on the assembly of mitotic and meiotic kinetochores in Saccharomyces cerevisiae. Mehta GD, et al. Mol Microbiol, 2014 Mar. PMID 24446862
    4. Dbf4 Zn-Finger Motif Is Specifically Required for Stimulation of Ctf19-Activated Origins in Saccharomyces cerevisiae. Petrie MV, et al. Genes (Basel), 2022 Nov 24. PMID 36553469, Free PMC Article
    5. The [PSI (+)] yeast prion does not wildly affect proteome composition whereas selective pressure exerted on [PSI (+)] cells can promote aneuploidy. Chan PHW, et al. Sci Rep, 2017 Aug 16. PMID 28814753, Free PMC Article

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dbf4 Zn-Finger Motif Is Specifically Required for Stimulation of Ctf19-Activated Origins in Saccharomyces cerevisiae.
      Title: Dbf4 Zn-Finger Motif Is Specifically Required for Stimulation of Ctf19-Activated Origins in Saccharomyces cerevisiae.
    2. Cdc4 phospho-degrons allow differential regulation of Ame1(CENP-U) protein stability across the cell cycle.
      Title: Cdc4 phospho-degrons allow differential regulation of Ame1(CENP-U) protein stability across the cell cycle.
    3. The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19(CCAN) Complex in Meiotic Kinetochore Assembly.
      Title: The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19(CCAN) Complex in Meiotic Kinetochore Assembly.
    4. A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination.
      Title: A dCas9-Based System Identifies a Central Role for Ctf19 in Kinetochore-Derived Suppression of Meiotic Recombination.
    5. Ctf19 is also essential for meiosis I specific unique events, such as non-homologous centromere coupling, homologue pairing, chiasmata resolution and proper orientation of homologues and sister chromatids with respect to the spindle poles.
      Title: Functional characterization of kinetochore protein, Ctf19 in meiosis I: an implication of differential impact of Ctf19 on the assembly of mitotic and meiotic kinetochores in Saccharomyces cerevisiae.
    6. The Ctf19 complex is required for Scc2 enrichment at the centromere.
      Title: Cohesin-dependent association of scc2/4 with the centromere initiates pericentromeric cohesion establishment.
    7. Ctf19 and Csm3 are both important mediators of pericentromeric cohesion.
      Title: Establishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to chromosome, centromeric region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COMA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ctf19p
    NP_015307.1
    • Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      517651..518760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183832.1 → NP_015307.1  TPA: Ctf19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015307.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3Z4, Q02732
      UniProtKB/TrEMBL
      A6ZWM8, C8ZJ10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02732.1

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