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    OSM1 fumarate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853510, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OSM1
    Official Full Name
    fumarate reductase
    Primary source
    SGD:S000003812
    Locus tag
    YJR051W
    See related
    AllianceGenome:SGD:S000003812; FungiDB:YJR051W; VEuPathDB:YJR051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables fumarate reductase (NADH) activity. Involved in FAD metabolic process and protein folding in endoplasmic reticulum. Located in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OSM1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (529861..531366)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene NADH/NAD(+) kinase Neighboring gene Isy1p Neighboring gene tRNA-Gly Neighboring gene UV-damaged DNA-binding protein RAD7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preparation of stable recombinant Osm1 noncovalently bound with flavin adenosine dinucleotide cofactor for structural study. Kim S, et al. Acta Crystallogr F Struct Biol Commun, 2019 Mar 1. PMID 30839289, Free PMC Article
    2. Physical analysis of the CYC1-sup4 interval in Saccharomyces cerevisiae. Shalit P, et al. Mol Cell Biol, 1981 Mar. PMID 6765599, Free PMC Article
    3. A mutator affecting the region of the iso-1-cytochrome c gene in yeast. Liebman SW, et al. Genetics, 1979 Jul. PMID 231539, Free PMC Article
    4. Deletions of the iso-1-cytochrome c and adjacent genes of yeast: discovery of the OSM1 gene controlling osmotic sensitivity. Singh A, et al. Genetics, 1978 Aug. PMID 211068, Free PMC Article
    5. Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling. Williams CC, et al. Science, 2014 Nov 7. PMID 25378625, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It has been concluded that soluble eukaryotic fumarate reductases can maintain an oxidizing environment under anaerobic conditions, either by oxidizing cellular flavin cofactors or by a direct interaction with flavoenzymes such as Ero1.
      Title: Molecular basis of maintaining an oxidizing environment under anaerobiosis by soluble fumarate reductase.
    2. Authors show that the fumarate reductase Osm1, which facilitates electron transfer from fumarate to succinate, fills this gap as a new electron acceptor. In addition to microsomes, Osm1 localizes to the mitochondrial intermembrane space and assembles with Erv1 in a complex.
      Title: Osm1 facilitates the transfer of electrons from Erv1 to fumarate in the redox-regulated import pathway in the mitochondrial intermembrane space.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fumarate reductase (NADH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fumarate reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fumarate reductase (NADH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in FAD metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding in endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fumarate reductase
    NP_012585.1
    • Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; acts as electron acceptor in mitochondrial intermembrane space; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      529861..531366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181709.1 → NP_012585.1  TPA: fumarate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWM2, P21375
      UniProtKB/TrEMBL
      A6ZQ10, B3LQE0, C7GVF5, D3UF98, G2WH56, N1P135
      Conserved Domains (1) summary
      TIGR01813
      Location:36 → 495
      flavo_cyto_c; flavocytochrome c
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21375.3

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