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    SPC1 signal peptidase complex subunit SPC1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853467, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPC1
    Official Full Name
    signal peptidase complex subunit SPC1
    Primary source
    SGD:S000003770
    Locus tag
    YJR010C-A
    See related
    AllianceGenome:SGD:S000003770; FungiDB:YJR010C-A; VEuPathDB:YJR010C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein targeting to ER and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SPC1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (458077..458361, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Neighboring gene sulfate adenylyltransferase Neighboring gene Cal4p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spc1 regulates the signal peptidase-mediated processing of membrane proteins. Yim C, et al. J Cell Sci, 2021 Jul 1. PMID 34125229, Free PMC Article
    2. The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae. Fang H, et al. J Biol Chem, 1996 Jul 12. PMID 8663399
    3. Differential requirements for actin during yeast and mammalian endocytosis. Aghamohammadzadeh S, et al. Nat Cell Biol, 2009 Aug. PMID 19597484, Free PMC Article
    4. In addition to SEC11, a newly identified gene, SPC3, is essential for signal peptidase activity in the yeast endoplasmic reticulum. Fang H, et al. J Biol Chem, 1997 May 16. PMID 9148930
    5. Structurally related Spc1p and Spc2p of yeast signal peptidase complex are functionally distinct. Mullins C, et al. J Biol Chem, 1996 Nov 15. PMID 8910564

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spc1 regulates the signal peptidase-mediated processing of membrane proteins.
      Title: Spc1 regulates the signal peptidase-mediated processing of membrane proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to ER IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal peptide processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal peptidase complex subunit SPC1
    NP_012544.1
    • Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); regulates cellular levels of membrane proteins; homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      458077..458361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181667.1 → NP_012544.1  TPA: signal peptidase complex subunit SPC1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWI6, P46965
      UniProtKB/TrEMBL
      A6ZPX8, B3LQB0, C7GWK1, C8ZBG6, G2WH22, N1P109
      Conserved Domains (1) summary
      pfam06645
      Location:16 → 85
      SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46965.1

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