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    CTK2 Ctk2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853450, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CTK2
    Official Full Name
    Ctk2p
    Primary source
    SGD:S000003543
    Locus tag
    YJL006C
    See related
    AllianceGenome:SGD:S000003543; FungiDB:YJL006C; VEuPathDB:YJL006C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Involved in positive regulation of macromolecule biosynthetic process and protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. Part of CTDK-1 complex. Orthologous to human CCNT1 (cyclin T1) and CCNT2 (cyclin T2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CTK2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (423138..424109, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT8 Neighboring gene uncharacterized protein Neighboring gene tRNA-Met Neighboring gene tRNA-Leu Neighboring gene adenylate cyclase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification and crystallization of the complex of RNA polymerase II carboxyl-terminal repeat domain kinase subunits CTK2-CTK3 from Saccharomyces cerevisiae. Zhu W, et al. Protein Expr Purif, 2019 Feb. PMID 30240633
    2. The yeast C-type cyclin Ctk2p is phosphorylated and rapidly degraded by the ubiquitin-proteasome pathway. Hautbergue G, et al. Mol Cell Biol, 1999 Apr. PMID 10082518, Free PMC Article
    3. The cyclin family of budding yeast: abundant use of a good idea. Andrews B, et al. Trends Genet, 1998 Feb. PMID 9520600
    4. Budding yeast CTDK-I is required for DNA damage-induced transcription. Ostapenko D, et al. Eukaryot Cell, 2003 Apr. PMID 12684377, Free PMC Article
    5. Activation of the cyclin-dependent kinase CTDK-I requires the heterodimerization of two unstable subunits. Hautbergue G, et al. J Biol Chem, 2001 Mar 16. PMID 11118453

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
      Title: Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription, elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of translational fidelity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CTDK-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cyclin/CDK positive transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ctk2p
    NP_012528.1
    • Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      423138..424109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181440.1 → NP_012528.1  TPA: Ctk2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWG9, P46962
      UniProtKB/TrEMBL
      B3LQ93, C7GV40, C8ZBK5, G2WH04, N1P0Z2
      Conserved Domains (1) summary
      COG5333
      Location:1 → 299
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P46962.1

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