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    BIO2 biotin synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853203, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BIO2
    Official Full Name
    biotin synthase
    Primary source
    SGD:S000003518
    Locus tag
    YGR286C
    See related
    AllianceGenome:SGD:S000003518; FungiDB:YGR286C; VEuPathDB:YGR286C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables biotin synthase activity. Involved in biotin biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BIO2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1063813..1064940, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Erv29p Neighboring gene zuotin Neighboring gene oligo-1,6-glucosidase IMA1 Neighboring gene transcription factor MAL13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The gene for biotin synthase from Saccharomyces cerevisiae: cloning, sequencing, and complementation of Escherichia coli strains lacking biotin synthase. Zhang S, et al. Arch Biochem Biophys, 1994 Feb 15. PMID 8117110
    2. Cloning of Schizosaccharomyces pombe bio2 by heterologous complementation of a Saccharomyces cerevisiae mutant. Phalip V, et al. Curr Microbiol, 1999 Dec. PMID 10525840
    3. Characterization of the cDNA and gene coding for the biotin synthase of Arabidopsis thaliana. Weaver LM, et al. Plant Physiol, 1996 Mar. PMID 8819873, Free PMC Article
    4. Biotin sensing in Saccharomyces cerevisiae is mediated by a conserved DNA element and requires the activity of biotin-protein ligase. Pirner HM, et al. J Biol Chem, 2006 May 5. PMID 16531611
    5. Cellular and mitochondrial remodeling upon defects in iron-sulfur protein biogenesis. Hausmann A, et al. J Biol Chem, 2008 Mar 28. PMID 18227070

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables biotin synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables biotin synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biotin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biotin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biotin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in water-soluble vitamin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    biotin synthase
    NP_011802.1
    • Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1063813..1064940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181415.1 → NP_011802.1  TPA: biotin synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011802.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV63, P32451
      UniProtKB/TrEMBL
      A6ZUU2, B3LHV9, B5VJN0, C7GNE9, C8Z9H9, G2WF09, N1P6H7
      Conserved Domains (1) summary
      PLN02389
      Location:9 → 375
      PLN02389; biotin synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32451.2

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