FET5 ferroxidase FET5 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: FET5
Official Full Name: ferroxidase FET5
Primary source: SGD:S000001853
Locus tag: YFL041W
See related: AllianceGenome:SGD:S000001853; FungiDB:YFL041W; VEuPathDB:YFL041W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ferroxidase activity. Involved in iron ion transport. Located in fungal-type vacuole membrane and membrane raft. Human ortholog(s) of this gene implicated in aceruloplasminemia; epilepsy; and hemosiderosis. Orthologous to human CP (ceruloplasmin); HEPH (hephaestin); and HEPHL1 (hephaestin like 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome VI - NC_001138.5 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables ferroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferroxidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to iron ion starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info
involved_in iron ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in reductive iron assimilation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

NP_116612.1

Multicopper oxidase; integral membrane protein with similarity to Fet3p; targeted to vacuole via AP-3 pathway; may have role in iron transport

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The following sections contain reference sequences that belong to a specific genome build. Explain