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    CORO6 coronin 6 [ Homo sapiens (human) ]

    Gene ID: 84940, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CORO6provided by HGNC
    Official Full Name
    coronin 6provided by HGNC
    Primary source
    HGNC:HGNC:21356
    See related
    Ensembl:ENSG00000167549 AllianceGenome:HGNC:21356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ClipinE
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and cell migration. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart (RPKM 15.3), placenta (RPKM 14.7) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CORO6 in Genome Data Viewer
    Location:
    17q11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (29614762..29622912, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (30557663..30565813, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (27941780..27949930, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27911138-27911952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27911953-27912765 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27914948-27915847 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:27916747-27917646 Neighboring gene tumor protein p53 inducible protein 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11982 Neighboring gene ankyrin repeat domain 13B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27940429-27941292 Neighboring gene GIT ArfGAP 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:27942158-27943021 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8384 Neighboring gene Sharpr-MPRA regulatory region 12866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8385 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:27950531-27951730 Neighboring gene NANOG hESC enhancer GRCh37_chr17:27960948-27961512 Neighboring gene uncharacterized LOC107984990 Neighboring gene Sharpr-MPRA regulatory region 11433 Neighboring gene RNA, U6 small nuclear 920, pseudogene Neighboring gene slingshot protein phosphatase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma. Morris MR, et al. Oncogene, 2011 Mar 24. PMID 21132003
    2. MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells. Cardinali B, et al. Cell Death Dis, 2016 Feb 4. PMID 26844700, Free PMC Article
    3. Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4. Li D, et al. Nat Commun, 2018 Jul 19. PMID 30026490, Free PMC Article
    4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. Wan D, et al. Proc Natl Acad Sci U S A, 2004 Nov 2. PMID 15498874, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14871

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    coronin-6
    Names
    clipin-E
    coronin, actin binding protein 6
    coronin-like protein E

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054920.1 RefSeqGene

      Range
      4997..13147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001351301.3 → NP_001338230.1  coronin-6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104564
      UniProtKB/TrEMBL
      B3KRY9
      Conserved Domains (1) summary
      cl29593
      Location:21 → 231
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001351302.3 → NP_001338231.1  coronin-6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC104564
      UniProtKB/TrEMBL
      B3KRY9
      Related
      ENST00000469090.5
      Conserved Domains (1) summary
      cl29593
      Location:21 → 231
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001388431.1 → NP_001375360.1  coronin-6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC104564
      Consensus CDS
      CCDS11252.2
      UniProtKB/Swiss-Prot
      B3KU26, Q6QEF8, Q71MF3, Q8WYH7, Q96K02
      Related
      ENSP00000344562.5, ENST00000345068.9
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 454
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001388433.1 → NP_001375362.1  coronin-6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104564
      UniProtKB/TrEMBL
      J3KSS5
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 465
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. NM_001388434.1 → NP_001375363.1  coronin-6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC104564
      UniProtKB/TrEMBL
      J3KSS5
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 465
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. NM_001388435.1 → NP_001375364.1  coronin-6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC104564
      UniProtKB/TrEMBL
      J3QLV6
      Conserved Domains (2) summary
      sd00039
      Location:31 → 88
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 413
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. NM_001388436.1 → NP_001375365.1  coronin-6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC104564
      UniProtKB/TrEMBL
      J3QLV6
      Related
      ENSP00000463723.1, ENST00000580212.6
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 425
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. NM_001388437.1 → NP_001375366.1  coronin-6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC104564
      UniProtKB/TrEMBL
      J3QLV6
      Conserved Domains (2) summary
      sd00039
      Location:31 → 88
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 424
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. NM_001388438.1 → NP_001375367.1  coronin-6 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC104564
      UniProtKB/TrEMBL
      J3QLV6
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 379
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. NM_032854.4 → NP_116243.2  coronin-6 isoform 1

      See identical proteins and their annotated locations for NP_116243.2

      Status: VALIDATED

      Source sequence(s)
      AC104564
      Consensus CDS
      CCDS11252.2
      UniProtKB/Swiss-Prot
      B3KU26, Q6QEF8, Q71MF3, Q8WYH7, Q96K02
      Related
      ENSP00000373419.3, ENST00000388767.8
      Conserved Domains (2) summary
      sd00039
      Location:37 → 79
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:9 → 454
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_170977.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104564

    2. NR_170978.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC104564

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      29614762..29622912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525387.4 → XP_011523689.1  coronin-6 isoform X2

      Conserved Domains (5) summary
      PTZ00421
      Location:80 → 484
      PTZ00421; coronin; Provisional
      pfam08953
      Location:78 → 135
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:374 → 416
      WD40_4; Type of WD40 repeat
      sd00039
      Location:102 → 159
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:106 → 326
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_011525386.4 → XP_011523688.1  coronin-6 isoform X1

      UniProtKB/TrEMBL
      J3QLV6
      Conserved Domains (5) summary
      PTZ00421
      Location:80 → 490
      PTZ00421; coronin; Provisional
      pfam08953
      Location:78 → 135
      DUF1899; Domain of unknown function (DUF1899)
      pfam16300
      Location:380 → 422
      WD40_4; Type of WD40 repeat
      sd00039
      Location:108 → 150
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:149 → 322
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_011525390.4 → XP_011523692.1  coronin-6 isoform X6

      See identical proteins and their annotated locations for XP_011523692.1

      UniProtKB/TrEMBL
      B3KRY9, B3KSZ9
      Conserved Domains (1) summary
      cl25676
      Location:21 → 220
      WD40_4; Type of WD40 repeat

    4. XM_011525391.4 → XP_011523693.1  coronin-6 isoform X6

      See identical proteins and their annotated locations for XP_011523693.1

      UniProtKB/TrEMBL
      B3KRY9, B3KSZ9
      Conserved Domains (1) summary
      cl25676
      Location:21 → 220
      WD40_4; Type of WD40 repeat

    5. XM_011525388.3 → XP_011523690.1  coronin-6 isoform X3

      Conserved Domains (3) summary
      pfam08953
      Location:78 → 135
      DUF1899; Domain of unknown function (DUF1899)
      sd00039
      Location:108 → 150
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:149 → 367
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_047436948.1 → XP_047292904.1  coronin-6 isoform X4

    7. XM_011525389.4 → XP_011523691.1  coronin-6 isoform X5

      See identical proteins and their annotated locations for XP_011523691.1

      Conserved Domains (3) summary
      pfam08953
      Location:78 → 135
      DUF1899; Domain of unknown function (DUF1899)
      sd00039
      Location:108 → 150
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:149 → 283
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      30557663..30565813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317584.1 → XP_054173559.1  coronin-6 isoform X2

    2. XM_054317583.1 → XP_054173558.1  coronin-6 isoform X1

    3. XM_054317588.1 → XP_054173563.1  coronin-6 isoform X6

      UniProtKB/TrEMBL
      B3KSZ9

    4. XM_054317589.1 → XP_054173564.1  coronin-6 isoform X6

      UniProtKB/TrEMBL
      B3KSZ9

    5. XM_054317585.1 → XP_054173560.1  coronin-6 isoform X3

    6. XM_054317586.1 → XP_054173561.1  coronin-6 isoform X4

    7. XM_054317587.1 → XP_054173562.1  coronin-6 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6QEF8.2 GenPept UniProtKB/Swiss-Prot:Q6QEF8

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