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    SEC6 SEC6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843512, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SEC6
    Official Full Name
    SEC6
    Primary source
    TAIR:AT1G71820
    Locus tag
    AT1G71820
    See related
    Araport:AT1G71820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14O23.20; F14O23_20
    Summary
    Encodes a member of the exocyst complex gene family. The exocyst is a protein complex involved in tethering vesicles to the plasma membrane during regulated or polarized secretion.
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    Genomic context

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    See SEC6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Sequence:
    Chromosome: 1; NC_003070.9 (27009564..27017124)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Subunits of heterodimeric actin filament capping protein Capz superfamily Neighboring gene cleavage stimulating factor 64 Neighboring gene Protein kinase superfamily protein Neighboring gene ncRNA Neighboring gene somatic embryogenesis receptor-like kinase 1 Neighboring gene transducin family protein / WD-40 repeat family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis exocyst subunit SEC6 is involved in cell plate formation during Microgametogenesis. Tan X, et al. Biochem Biophys Res Commun, 2022 Apr 2. PMID 35151976
    2. Mutations in exocyst complex subunit SEC6 gene impaired polar auxin transport and PIN protein recycling in Arabidopsis primary root. Tan X, et al. Plant Sci, 2016 Sep. PMID 27457987
    3. Regulation of cytokinesis by exocyst subunit SEC6 and KEULE in Arabidopsis thaliana. Wu J, et al. Mol Plant, 2013 Nov. PMID 23702595
    4. Exo70E2 is essential for exocyst subunit recruitment and EXPO formation in both plants and animals. Ding Y, et al. Mol Biol Cell, 2014 Feb. PMID 24307681, Free PMC Article
    5. An exocyst complex functions in plant cell growth in Arabidopsis and tobacco. Hála M, et al. Plant Cell, 2008 May. PMID 18492870, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEC1A and SEC6 synergistically regulate pollen tube polar growth.
      Title: SEC1A and SEC6 synergistically regulate pollen tube polar growth.
    2. Arabidopsis exocyst subunit SEC6 is involved in cell plate formation during Microgametogenesis.
      Title: Arabidopsis exocyst subunit SEC6 is involved in cell plate formation during Microgametogenesis.
    3. In PRsec6 mutants, primary root growth was retarded, and lateral root initiation were compromised. Primary roots were sensitive to exogenous auxin 1-napthalene acetic acid but not 2,4-dichlorophenoxy. The results further demonstrated that the exocyst complex plays an important role in PIN protein recycling and polar auxin transport in Arabidopsis primary root.
      Title: Mutations in exocyst complex subunit SEC6 gene impaired polar auxin transport and PIN protein recycling in Arabidopsis primary root.
    4. results demonstrated that, like KEULE, SEC6 plays a physiological role in cytokinesis, and the SEC6-KEULE interaction may serve as a novel molecular linkage between arriving vesicles and membrane fusion
      Title: Regulation of cytokinesis by exocyst subunit SEC6 and KEULE in Arabidopsis thaliana.
    5. SEC6 copurifies in a high molecular mass fraction of 900 kD, interacts with SEC8, and functions as a subunit in a exocyst complex that plays important roles in morphogenesis.
      Title: An exocyst complex functions in plant cell growth in Arabidopsis and tobacco.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105840.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acceptance of pollen IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    SEC6
    NP_001185374.1
    • SEC6; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: pollen germination, pollen tube growth; LOCATED IN: cytosol, exocyst; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Exocyst complex component Sec6 (InterPro:IPR010326).
    NP_565026.1
    • SEC6; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: pollen germination, pollen tube growth; LOCATED IN: cytosol, plasma membrane, exocyst; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Exocyst complex component Sec6 (InterPro:IPR010326); Has 534 Blast hits to 527 proteins in 171 species: Archae - 3; Bacteria - 6; Metazoa - 247; Fungi - 146; Plants - 73; Viruses - 0; Other Eukaryotes - 59 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27009564..27017124
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198445.1 → NP_001185374.1  SEC6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185374.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WN94, F4IA34
      Conserved Domains (1) summary
      pfam06046
      Location:173 → 759
      Sec6; Exocyst complex component Sec6

    2. NM_105840.4 → NP_565026.1  SEC6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565026.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RVQ6, Q94AI6, Q9M9G4
      UniProtKB/TrEMBL
      A0A178WN94, A0A5S9WRP0, A0A654EYW6
      Conserved Domains (1) summary
      pfam06046
      Location:173 → 737
      Sec6; Exocyst complex component Sec6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AI6.1

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